Effect of Physical Activity Pattern on Cardiometabolic Health

NCT ID: NCT05838508

Last Updated: 2025-06-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-11

Study Completion Date

2026-08-30

Brief Summary

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The goal of this study is to understand the interaction between the circadian system and physical activity.

Participants will:

* complete 2 inpatient stays
* perform moderate exercise
* be provided with identical meals
* have frequent blood draws
* provide urine and saliva samples

Detailed Description

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The endogenous circadian system (i.e., an internal biological rhythm) plays an important role in regulating blood glucose, blood pressure, and energy expenditure. Physical activity improves health and reduces the risk for cardiovascular diseases and type 2 diabetes. The goal of this study is to understand the interaction between the circadian system and physical activity. We aim to test whether such relationship between the circadian system and physical activity can be used to enhance the health benefits of physical activity.

Conditions

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Life Style

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Exercise A-B Intervention

The Exercise A first, then the Exercise B intervention.

Group Type EXPERIMENTAL

Exercise intervention

Intervention Type BEHAVIORAL

Research participants will be assigned to two exercise conditions.

Exercise B-A Intervention

The Exercise B first, then the Exercise A intervention.

Group Type EXPERIMENTAL

Exercise intervention

Intervention Type BEHAVIORAL

Research participants will be assigned to two exercise conditions.

Interventions

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Exercise intervention

Research participants will be assigned to two exercise conditions.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* 18-45 yr old
* Body mass index (BMI) 18.5 - 34.9 kg/m2
* No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)
* Willing to adhere to the protocol requirements for the duration of the study

Exclusion Criteria

* Currently smoking/vaping or 5 or more years of smoking/vaping
* Currently pregnant or breastfeeding
* History of drug or alcohol dependency
* History of psychiatric illness or disorder
* Any hospitalization due to COVID-19
* Inability to exercise for any reason
* Any known contraindication to exercise testing based on current ACSM guidelines
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role collaborator

Brigham and Women's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jingyi Qian

Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jingyi Qian, PhD

Role: PRINCIPAL_INVESTIGATOR

Brigham and Women's Hospital

Locations

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Brigham and Women's Hospital

Boston, Massachusetts, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Jingyi Qian, PhD

Role: CONTACT

6175257423

Vy Nguyen, B.S.

Role: CONTACT

617-525-0662

Facility Contacts

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Jingyi Qian, PhD

Role: primary

6175257423

Vy Nguyen, B.S.

Role: backup

617-525-0662

Other Identifiers

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R00HL148500

Identifier Type: NIH

Identifier Source: secondary_id

View Link

2023P001025

Identifier Type: -

Identifier Source: org_study_id

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