Effects of Different Types of Exercise on Cognitive Function in Postmenopausal Hypertensive Women

NCT ID: NCT05898503

Last Updated: 2023-06-12

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 183 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-04-23
• Study Completion Date: 2024-12-31

Brief Summary

Brief Summary: The study was conducted in two parts, the first of which was carried out using a cross-sectional design approach to explore the relationship between cognitive function and autonomic function, brain function, inflammation and oxidative stress, vascular function, fitness levels, cardiorespiratory endurance and lipid metabolism. The second part uses a repeated measures design approach in a randomised controlled design to explore the effects of different types of exercise on cognitive decline in postmenopausal hypertensive women and their mechanisms of action.

Detailed Description

Detailed Description: The study was conducted in 2 parts. Part I: was conducted using a cross-sectional design approach to explore the relationship between cognitive function and autonomic function, brain function, inflammation and oxidative stress, vascular function, fitness levels, cardiorespiratory endurance and lipid metabolism. Multiple linear regression was used to analyse the multiple linear relationships between changes in cognitive function and the above influences. Multiple logistic regression analysis was also used to analyse which of the above risk factors might be independent predictors of cognitive decline. Therefore, a combination of both regression analyses was used to further explore the multiple linear relationships between cognitive function and the aforementioned influencing factors, providing a viable causal and theoretical basis for the next exercise intervention.

The second part of the study is to test the viability of the vascular function theory. The "vascular function theory" refers to the use of exercise to improve aerobic capacity, improve blood circulation to the heart, and improve cerebrovascular function, which in turn improves cognitive function. Based on the above hypothesis, this study aims to investigate the possible effects of 12 weeks of different types of exercise on cognitive decline in post-menopausal women with HTN, and to lay the theoretical and practical foundation for the extension of the exercise intervention to other ages and populations.

Conditions

Cognitive Function; Hypertension

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: SINGLE

Study Groups

Combined training group

Group Type: EXPERIMENTAL

Walking exercise + resistance training

Intervention Type: BEHAVIORAL

Walking exercise and resistance training for 12 weeks

Resistance training group

Group Type: EXPERIMENTAL

Resistance training

Intervention Type: BEHAVIORAL

Resistance training for 12 weeks

Walking exercise group

Group Type: EXPERIMENTAL

Walking exercise

Intervention Type: BEHAVIORAL

Walking exercise for 12 weeks

Positive control group

Group Type: ACTIVE_COMPARATOR

Health promotion

Intervention Type: BEHAVIORAL

Health promotion for 12 weeks

Negative control group

Group Type: SHAM_COMPARATOR

Health promotion

Intervention Type: BEHAVIORAL

Health promotion for 12 weeks

Interventions

Walking exercise + resistance training

Walking exercise and resistance training for 12 weeks

Intervention Type: BEHAVIORAL

Resistance training

Resistance training for 12 weeks

Intervention Type: BEHAVIORAL

Walking exercise

Walking exercise for 12 weeks

Intervention Type: BEHAVIORAL

Health promotion

Health promotion for 12 weeks

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

1. postmenopausal women aged 55 to 65 years

2. SBP ≥ 120 mmHg, DBP < 90 mmHg

3. good physical condition

4. practice daily exercise (more than 6000 times daily)

5. do not drink or smoke

6. have a risk classification of no risk for cardiovascular disease

7. voluntary participation

Exclusion Criteria

1 pre-menopausal, not falling under the above conditions 2 blood pressure not exceeding the above range 3 refractory hypertension and secondary hypertension 4 metabolic and cardiovascular diseases 5 unable to exercise for their own reasons 6 regular exercise (more than 6,000 steps per day) 7 poor lifestyle habits such as alcohol and smoking 8 suffering from cardiovascular disease risk classification of high or low

b.

1. pre-menopausal and not in the above category

2. SBP and DBP values below normal

3. general health, disability or other medical conditions

4. poor diet, alcohol abuse, smoking, etc.

5. no low risk cardiovascular risk classification

• Minimum Eligible Age: 55 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Beijing Sport University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

School of Sports Medicine and Rehabilitation, Beijing Sport University

Beijing, , China

Site Status: RECRUITING

Countries

China

Central Contacts

Peizhen Zhang

Role: CONTACT

zhpzh@bsu.edu.cn

01062989581

Facility Contacts

Peizhen Zhang

Role: primary

zhpzh@bsu.edu.cn

Other Identifiers

EODTOEOCFIPHW

Identifier Type: -

Identifier Source: org_study_id