Effects of Aerobic Exercise on Blood Pressure Levels of Resistant Hypertensive Subjects

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-11-30

Study Completion Date

2019-03-31

Brief Summary

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The aim of this intervention study is to evaluate the acute and chronic effects of different intensity (mild, moderate and high intensity) of aerobic exercise on blood pressure levels of subjects classified as resistant hypertension. Resistant hypertensives subjects aged 40 to 70, men or women with body mass index lower that 40 kg/m² are recruited and subjected in acute phase in three sessions of aerobic exercise: mild, moderate, high intensity; and session control. After, the subjects will be randomly allocated into four intervention groups: mild intensity group, moderate intensity group, high intensity group and control group. In both phases, the subjects have blood pressure data recorded by ambulatory blood pressure monitoring, for clinic and ambulatory analysis. In addition, continuously be registered biological signs of blood pressure (finometer), electrocardiogram (DII derivation) and blood flow (venous occlusion plethysmography) for analysis of cardiac autonomic modulation, vascular autonomic modulation, baroreflex sensitivity, vasodilator response and peripheral vascular resistance.

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Detailed Description

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Conditions

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Hypertension Resistant Hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Aerobic Exercise Mild Intensity

The subjects engage in aerobic exercise training (8 weeks) of mild intensity (continuous). The intensity is controlled by a corresponding heart rate at anaerobic threshold.

Group Type ACTIVE_COMPARATOR

Aerobic Exercise Training

Intervention Type BEHAVIORAL

8 week of aerobic exercise training in different intensities.

Aerobic Exercise Moderate Intensity

The subjects engage in aerobic exercise training (8 weeks) of moderate intensity (continuous). The intensity is controlled by a corresponding heart rate between anaerobic threshold and respiratory compensation point.

Group Type ACTIVE_COMPARATOR

Aerobic Exercise Training

Intervention Type BEHAVIORAL

8 week of aerobic exercise training in different intensities.

Aerobic Exercise High Intensity

The subjects engage in aerobic exercise (8 weeks) of high intensity interval training. The intensity is controlled by a corresponding heart rate above respiratory compensation point.

Group Type ACTIVE_COMPARATOR

Aerobic Exercise Training

Intervention Type BEHAVIORAL

8 week of aerobic exercise training in different intensities.

Interventions

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Aerobic Exercise Training

8 week of aerobic exercise training in different intensities.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Age between 40 and 70 years
* Men or women
* Body mass index under 40 kg / m²
* Able to participate in exercise
* No regular physically active in the last 4 months

Exclusion Criteria

\- Smoking; with history of ischemic stroke or hemorrhagic; or coronary heart disease; or obstructive pulmonary disease or chronic restrictive; or diabetes mellitus; or chronic atrial fibrillation.

Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No