High-Intensity Interval Training on Pre-Hypertensive Subjects

NCT ID: NCT03000140

Last Updated: 2018-10-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

142 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-03-31

Study Completion Date

2017-02-28

Brief Summary

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Despite exercise training decrease blood pressure in 'average' terms, there is a wide interindividual variability after exercise training, being yet unknown what mode of exercise (e.g. endurance, strength, concurrent, or high intensity interval training) produce more/less non-responder (NR) prevalence (i.e., percentage of subjects who experienced a non-change/worsened response after training in some outcome).

Detailed Description

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Despite exercise training decrease blood pressure in 'average' terms, there is a wide interindividual variability after exercise training, being yet unknown what mode of exercise (e.g. endurance, strength, concurrent, or high intensity interval training) produce more/less non-responder (NR) prevalence (i.e., percentage of subjects who experienced a non-change/worsened response after training in some outcome).

Conditions

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Metabolism Disorder Hypertension

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Investigators

Study Groups

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High Intensity Interval Training

Cycling on cycle ergometers (OXFORDTM, model BE2601, OXOFORD Inc, Santiago, Chile) for 1 min at a subjective intensity of 8-10 points of the modified Borg scale of 1-10 points, and interspersed by inactive (without movement over the bicycle) of 2 minutes as recovery period.

Group Type EXPERIMENTAL

High Intensity Interval Training

Intervention Type BEHAVIORAL

High Intensity Interval Training pre-hypertensive group; Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 16 weeks.

Control group

Pre-hypertensive group was compared with healthy groups in the 2 manin variables systolic/diastolic blood pressure, as well as in other co-variables in pre-post changes. Thus, after the training intervention, and following the R and NR classification, we will compare the NR prevalence between both Pre-hypertensive and Healthy group.

Group Type ACTIVE_COMPARATOR

Control group

Intervention Type BEHAVIORAL

Moderade Intensity Interval Training pre-hypertensive group; Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 16 weeks.

Interventions

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High Intensity Interval Training

High Intensity Interval Training pre-hypertensive group; Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 16 weeks.

Intervention Type BEHAVIORAL

Control group

Moderade Intensity Interval Training pre-hypertensive group; Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 16 weeks.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Written informed consent;
* Interested in improving health and fitness;
* Systolic blood pressure \> 120 mmHg and \< 140 mmHg, and/or DBP ≥ 80 and \< 90 mmHg according with standard classification;
* No drug therapy during the previous 3 months;
* Body mass index (BMI) 25 and 35 kg/m2); (c) physically inactive (according to the International Physical Activity Questionnaire previously validated in Chilean population)
* Normal /mild altered lipid profile (total cholesterol \[TC\] \~200 and ≤250 mg/dL, low-density lipids \[LDL-C\] \~140 mg/dL and ≤200 mg/dL, high-density lipids \[HDL-C\] ≥20 and \~40 mg/dL, triglycerides \~150 and ≤250 mg/dL) according with standard classification.

Exclusion Criteria

* Cardiovascular contraindications to exercise histories of stroke;
* Asthma and chronic obstructive pulmonary disease;
* Musculoskeletal disorder such as low back pain;
* Smokers in the last 3 months were not included in the study.
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Healthcare Center Tomas Rojas

OTHER

Sponsor Role collaborator

University of Los Ríos

UNKNOWN

Sponsor Role collaborator

Universidad Pública de Navarra

OTHER

Sponsor Role collaborator

Universidad del Rosario

OTHER

Sponsor Role collaborator

Universidad Santo Tomas

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Cristian Alvarez

Osorno, , Chile

Site Status

Countries

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Chile

References

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Alvarez C, Ramirez-Campillo R, Cristi-Montero C, Ramirez-Velez R, Izquierdo M. Prevalence of Non-responders for Blood Pressure and Cardiometabolic Risk Factors Among Prehypertensive Women After Long-Term High-Intensity Interval Training. Front Physiol. 2018 Oct 23;9:1443. doi: 10.3389/fphys.2018.01443. eCollection 2018.

Reference Type DERIVED
PMID: 30405426 (View on PubMed)

Other Identifiers

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Number 03052015

Identifier Type: -

Identifier Source: org_study_id

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