High-intensity Intermittent Training for Obese Individuals

NCT ID: NCT01143376

Last Updated: 2017-04-20

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 46 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-05-31
• Study Completion Date: 2014-01-31

Brief Summary

The most appropriate and effective exercise interventions for weight loss remain a matter of continued discussion and there is a need to identify sustainable exercise programs which successfully promote weight loss and benefit health.

The primary objective of this study is to determine if high-intensity intermittent sprinting (HIIS) produces better results in terms of reducing metabolic and cardiovascular risk factors, with special emphasis to fat mass loss and insulin sensitivity in "healthy" obese volunteers compared with an iso-caloric program of moderate-intensity continuous cycling (MICC) (control condition following the international recommendations). We will also assess the impact of short duration sprints (SDS) in the above factors and to understand the potential mechanisms behind different outcomes among training programs.

The overall hypothesis is that HIIS will lead to a greater reduction in metabolic and cardiovascular risk factors compared with MICC in healthy obese volunteers and that SDS will produce similar improvements in cardiovascular risk factors as the longer duration HIIS

Detailed Description

Participants will be randomized to one of three groups: HIIS (8s sprint:12s rest) or MICC (control group) iso-caloric protocols (for the duration needed to induce a 250 kcal energy deficit) or SDS (8s sprint:12s rest) for 10 minutes for 12 weeks. The intervention groups will be matched for age, BMI and male/females ratio and participants will be asked not to change their normal diet throughout the study.

Before and after the exercise intervention (12 weeks), participants will perform the following assessments:

1. Three-day food diaries

2. Anthropometric measurements (weight, height, waist and hips) using standard procedures;

3. Body composition using dual energy x-ray absorptiometry (DEXA)

4. RMR and resting respiratory exchange ratio (RER) using indirect calorimetry;

5. Endothelial function assessed by flow-mediated dilation (FMD) of the brachial artery using vascular ultrasound according to current guidelines;

6. Maximal oxygen uptake (VO2max) and fat oxidation, cardiac output and left ventricular function during exercise using a cycle ergometer;

7. Muscle and fat biopsies

8. Fasting and postprandial release of appetite related hormones (and subjective feelings of hunger/fullness using visual analogue scales - VAS).

Conditions

Obesity

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Moderate intensity exercise

Moderate intensity exercise

Group Type: ACTIVE_COMPARATOR

Moderate intensity exercise

Intervention Type: BEHAVIORAL

High Intensity training

High Intensity intermittent training

Group Type: EXPERIMENTAL

High intensity training

Intervention Type: BEHAVIORAL

high-intensity intermittent sprinting (HIIS) (8 sec sprint:12 sec rest) for 12 weeks, 4 times a week

Short springs

short springs training

Group Type: EXPERIMENTAL

short springs

Intervention Type: BEHAVIORAL

short duration sprints (SDS)(8 sec sprint:12 sec rest) for 12 weeks, 4 times a week

Interventions

High intensity training

high-intensity intermittent sprinting (HIIS) (8 sec sprint:12 sec rest) for 12 weeks, 4 times a week

Intervention Type: BEHAVIORAL

short springs

short duration sprints (SDS)(8 sec sprint:12 sec rest) for 12 weeks, 4 times a week

Intervention Type: BEHAVIORAL

Moderate intensity exercise

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• weight stable on the last three months,
• not currently dieting to lose weight
• inactive lifestyle.

Exclusion Criteria

• History of endocrine/cardiovascular/pulmonary/kidney disease,
• anaemia,
• gout,
• depression or other psychological disorders,
• eating disorders,
• drug or alcohol abuse within the last two years
• current medication known to affect appetite or induce weight loss.
• planned surgery during the study period
• participation in another research study
• restraint score derived from the TFEQ>12
• post-menopausal women

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Helse Midt-Norge

OTHER

Sponsor Role: collaborator

Norwegian University of Science and Technology

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Catia Martins, PhD

Role: PRINCIPAL_INVESTIGATOR

Norwegian University of Science and Technology

Locations

Norwegian University of Science and Technology

Trondheim, , Norway

Countries

Norway

References

Martins C, Kazakova I, Ludviksen M, Mehus I, Wisloff U, Kulseng B, Morgan L, King N. High-Intensity Interval Training and Isocaloric Moderate-Intensity Continuous Training Result in Similar Improvements in Body Composition and Fitness in Obese Individuals. Int J Sport Nutr Exerc Metab. 2016 Jun;26(3):197-204. doi: 10.1123/ijsnem.2015-0078. Epub 2015 Oct 19.

Reference Type: RESULT

PMID: 26479856 (View on PubMed)

Martins C, Aschehoug I, Ludviksen M, Holst J, Finlayson G, Wisloff U, Morgan L, King N, Kulseng B. High-Intensity Interval Training, Appetite, and Reward Value of Food in the Obese. Med Sci Sports Exerc. 2017 Sep;49(9):1851-1858. doi: 10.1249/MSS.0000000000001296.

Reference Type: RESULT

PMID: 28398946 (View on PubMed)

Other Identifiers

2010/447

Identifier Type: -

Identifier Source: org_study_id