Effect of High-intensity Intermittent Sprinting on Appetite Control on Obese Volunteers

NCT ID: NCT01143363

Last Updated: 2015-02-06

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 12 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-05-31
• Study Completion Date: 2014-06-30

Brief Summary

Several studies have shown that high intensity intermittent sprints (HIIS) are more effective than moderate intensity continuous cycling (MICC) in reducing fat mass and improving insulin resistance in normal weight individuals. Changes in the appetite-regulatory system in response to exercise are likely to explain, at least partially, the better outcome observed after HIIS. Unfortunately, there are no studies comparing the impact of different types of acute aerobic exercise on the release of appetite-regulating hormones, subjective feelings of appetite and subsequent energy intake (EI).

The primary objective of this study is to investigate the effects of acute isocaloric bouts of HIIT and MICC or a short duration sprint, in comparison with a resting control condition, on the postprandial release of appetite-regulating hormones, subjective feelings of appetite and subsequent EI in obese individuals. The investigators hypothesize that an isocaloric session of HIIS will result in a better short-term appetite control compared with MICC, by reducing hunger feelings and subsequent food intake more than MICC and by inducing a larger increase in the release of satiety gut peptides compared with the MICC.

Detailed Description

This will be a randomised cross-over study with four legs. Participants will act as their own controls and will be assigned to the four experimental conditions (resting, HIIS, MICC and SDS), 1 week apart, in a counter-balanced order.

Participants will be asked to come to the Unit five times: one preliminary session and four experimental conditions (resting, HIIS and MICC isocaloric sessions and SDS). In the preliminary session, anthropometric data (weight and height) will be collected and a maximal fitness test performed, using a cycle ergometer.

For the four experimental conditions, participants will be asked to arrive at approximately 8.00, having fasted for at least 10 hours, and a cannula will be inserted into an antecubital vein. Two fasting blood samples will be taken and a standard breakfast offered. After that, serial blood samples will be taken at regular intervals for a period of 3h.

Participants will be asked to rate their subjective feelings of hunger and fullness using visual analogue scales (VAS) throughout each study morning at different time points. Three hours after breakfast, participants will be placed in individual rooms, presented with a standardized lunch and instructed to rate the taste and palatability of the food presented.

Conditions

Obesity

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Resting - control

No exercise

Group Type: PLACEBO_COMPARATOR

resting - control

Intervention Type: BEHAVIORAL

Moderate intensity exercise

Moderate intensity exercise (continuous) 1h after breakfast

Group Type: EXPERIMENTAL

Moderate intensity exercise

Intervention Type: BEHAVIORAL

High intensity intermittent training

High intensity intermittent training 1h after breakfast

Group Type: EXPERIMENTAL

High intensity intermittent training

Intervention Type: BEHAVIORAL

Short sprint

Short sprint 1h after breakfast

Group Type: EXPERIMENTAL

Short sprint

Intervention Type: BEHAVIORAL

Interventions

resting - control

Intervention Type: BEHAVIORAL

Moderate intensity exercise

Intervention Type: BEHAVIORAL

High intensity intermittent training

Intervention Type: BEHAVIORAL

Short sprint

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• an inactive lifestyle,
• weight stable on the previous 3 months,
• not currently dieting to loose weight
• restraint score derived from the Three Factor Eating Behaviour Questionnaire ≤12

Exclusion Criteria

• history of coronary heart disease,
• type 1 or type 2 diabetes,
• anaemia,
• gout,
• depression or other psychological disorders,
• eating disorders,
• drug or alcohol abuse within the last two years,
• current medication known to affect appetite or induce weight loss and hypertension.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Helse Midt-Norge

OTHER

Sponsor Role: collaborator

Norwegian University of Science and Technology

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Catia Martins, PhD

Role: PRINCIPAL_INVESTIGATOR

Norwegian University of Science and Technology

Locations

Norwegian University of Science and Technology

Trondheim, , Norway

Countries

Norway

References

Martins C, Stensvold D, Finlayson G, Holst J, Wisloff U, Kulseng B, Morgan L, King NA. Effect of moderate- and high-intensity acute exercise on appetite in obese individuals. Med Sci Sports Exerc. 2015 Jan;47(1):40-8. doi: 10.1249/MSS.0000000000000372.

Reference Type: RESULT

PMID: 24824772 (View on PubMed)

Other Identifiers

2010/444-7

Identifier Type: -

Identifier Source: org_study_id