Does the Timing of When High Intensity Intermittent Exercise is Undertaken Matter?

NCT ID: NCT04122209

Last Updated: 2019-10-17

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 12 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-10-16
• Study Completion Date: 2020-08-31

Brief Summary

The participants will visit the laboratory on 3 occasions, once for a preliminary visit and a further two occasions to complete experimental trials in a randomised order. The experimental trials will consist of cycling under two conditions; HIIE-First followed by Continuous (Trial-A) or Continuous-First followed by HIIE (Trial-B). Participants will be asked to standardise their diet for 24-hours and complete an overnight fast prior to visiting the laboratory. Participants will then complete 60-min of cycling split throughout the day into two 30-min bouts, HIIE or continuous cycling before breakfast followed by a 3.5 hour rest period before completing their remaining 30-min HIIE or Continuous cycling before lunch. Each experimental trail will last approximately 8 hours and begin at 08:00am. Throughout the trial measurements of subjective feelings of appetite, gastric emptying rate, substrate utilisation and regular blood samples will be taken. Post-trial nutritional and well-being questionnaires will be collected at 24-h post.

Study hypothesis

1. The order in which continuous and HIIE is undertaken will result in differences in gastric emptying rate after ingesting a semi-sold lunch?

2. Depending on which mode of exercise is undertaken first will result in different gastrointestinal hormone responses, metabolic responses and appetite responses throughout the trial day?

3. Will the order in which different modes of exercise, undertaken within the same day effect nutritional intake and well-being 24-h after both exercise bout have been completed?

4. Is substrate oxidation effected by the order in which multiple exercise bout of different modes are undertaken within the same day.

Detailed Description

There is a growing amount of literature committed to understanding if becoming more active will have beneficial effects on metabolic health; secondly do the traditional physical exercise and dietary approaches to managing obesity result in prolonged weight loss. The purpose of this study is to determine whether high intensity intermittent exercise (HIIE) and continuous exercise carried out in differing sequences within a day will have a beneficial health impact.

Participants will complete two 8h experimental trials in a randomised cross-over design. Each participant will complete 60-min of exercise in both trial arms; HIIE-First or Continuous-First separated by a minimum of 7 days. One trial will consist of a 30-min HIIE cycling session (10 x 1min of peak power output followed by 2min rest). After completion of this bout of exercise, participants will ingest a standardised breakfast. Following a rest period of 3h before completing the remaining 30-min of exercise (50% peak maximal oxygen uptake), before consuming a standardised semi-sold lunch meal. The second trial will be identical other than participates will undertake the continuous exercise first followed by the HIIE. Regular appetite, breath and blood samples will be taken throughout the trials. In The 24 hours following the end of each trial, participants will be asked to record their dietary intake and record their feeling of well-being documented on a questionnaire. There will be no long-term follow up following completion of the study.

Therefore, the aim of this research project is to identify whether the order of HIIE and continuous exercise separated within the day results in changes to gastrointestinal health, appetite, and metabolic responses.

Conditions

Weight Loss; Weight Change, Body; Nutritional and Metabolic Disease

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

HIIE-First

60-min of exercise split into; firstly 30-min HIIE (10 x 1min of PPO, followed by 2-min rest). Secondly 30-min of continuous exercise (50% peak maximal oxygen uptake).

Group Type: EXPERIMENTAL

HIIE-First

Intervention Type: OTHER

Multiple exercise bout during the same day; HIIE first followed by continuous exercise

Continuous-First

60-min of exercise split into; firstly 30-min of continuous exercise (50% peak maximal oxygen uptake). Secondly 30-min HIIE (10 x 1min of PPO, followed by 2-min rest)

Group Type: EXPERIMENTAL

Continuous-First

Intervention Type: OTHER

Multiple exercise bout during the same day; Continuous exercise first followed by HIIE

Interventions

HIIE-First

Multiple exercise bout during the same day; HIIE first followed by continuous exercise

Intervention Type: OTHER

Continuous-First

Multiple exercise bout during the same day; Continuous exercise first followed by HIIE

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. Healthy males

2. Age between 18-40 years

3. Body mass index = <29.9 kg/m2

4. Non-smokers

5. No history of GI symptoms

6. Not consuming prescription medication, or no other relevant medical conditions assessed by a medical screening questionnaire.

7. Not vegan or lactose intolerant

8. Subsequently be physically active, in order to complete the trials.

Exclusion Criteria

1. Not healthy

2. Female

3. Under 18 years

4. Over 40 years

5. Body mass index = >29.9 kg/m2;

6. Smokers

7. History of GI symptoms or disease,

8. Consuming prescription medication

9. Lactose Intolerant

10. Vegan

11. Subsequently not physically active, in order to complete the trials

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Manchester Metropolitan University

OTHER

Sponsor Role: lead

Responsible Party

Lewis R Mattin

Postgraduate Teaching assistant (Nutritional Physiology)

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Gethin H Evans, PhD

Role: STUDY_DIRECTOR

Manchester Metropolitan University

Locations

Manchester Metropolitan University

Manchester, , United Kingdom

Site Status: RECRUITING

Countries

United Kingdom

Central Contacts

Lewis R Mattin, MRs

Role: CONTACT

l.mattin@mmu.ac.uk

01612471215

Gethin H Evans, PhD

Role: CONTACT

gethin.evans@mmu.ac.uk

01612471208

Facility Contacts

Lewis R Mattin, MRs

Role: primary

l.mattin@mmu.ac.uk

01612471215

Gethin H Evans, PhD

Role: backup

gethin.evans@mmu.ac.uk

01612471208

References

Mattin LR, Yau AMW, McIver V, James LJ, Evans GH. The Effect of Exercise Intensity on Gastric Emptying Rate, Appetite and Gut Derived Hormone Responses after Consuming a Standardised Semi-Solid Meal in Healthy Males. Nutrients. 2018 Jun 19;10(6):787. doi: 10.3390/nu10060787.

Reference Type: BACKGROUND

PMID: 29921786 (View on PubMed)

McIver VJ, Mattin LR, Evans GH, Yau AMW. Diurnal influences of fasted and non-fasted brisk walking on gastric emptying rate, metabolic responses, and appetite in healthy males. Appetite. 2019 Dec 1;143:104411. doi: 10.1016/j.appet.2019.104411. Epub 2019 Aug 21.

Reference Type: BACKGROUND

PMID: 31445052 (View on PubMed)

McIver VJ, Mattin L, Evans GH, Yau AMW. The effect of brisk walking in the fasted versus fed state on metabolic responses, gastrointestinal function, and appetite in healthy men. Int J Obes (Lond). 2019 Sep;43(9):1691-1700. doi: 10.1038/s41366-018-0215-x. Epub 2018 Sep 24.

Reference Type: BACKGROUND

PMID: 30250241 (View on PubMed)

Other Identifiers

LRM-11619

Identifier Type: -

Identifier Source: org_study_id