High Intensity Interval Versus Continuous Moderate Intensity Training: Maximizing the Benefits of Exercise in Overweight Adolescents

NCT ID: NCT01935323

Last Updated: 2016-01-12

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-02-28
• Study Completion Date: 2014-12-31

Brief Summary

6-week, single site, two parallel arm, randomized, controlled trial comparing the effectiveness of a High Intensity Interval Training (HIIT) versus a continuous Moderate Intensity Training (MIT) program on cardiovascular and metabolic health outcomes in overweight adolescent males. HIIT training may be a potent time-efficient strategy to induce similar metabolic and cardiovascular adaptations typically associated with MIT.

Conditions

Metabolism; Physical Fitness

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: SINGLE

Study Groups

High Intensity Interval Training

Participants will perform the HIIT protocol on an electronically-braked cycle ergometer (Quinton Excalibur, Quinton Instrument Company, Bothell, WA). Participants will perform a 20-minute protocol, consisting of four minutes of cycling at 15% of maximum anaerobic power (Max-AP) followed by 30 seconds at 85% of Max-AP. These workloads will be based upon pre-trial Wingate tests. This cycle was repeated four times within each protocol, ending with two minutes at 15% of Max-AP. This will be performed 3d/wk for 6wks, with at least 24 hrs between each session.

Group Type: EXPERIMENTAL

High Intensity Interval Training

Intervention Type: OTHER

Moderate Intensity Training

Participants will perform 45-60 min (graduated over time to 60) of continuous cycling at 65% of VO¬2peak on a Monark cycle ergometer. Workload will be based upon pre-trial VO¬2peak testing. MIT exercise will be performed 5d/wk for 6wks.

Group Type: ACTIVE_COMPARATOR

Moderate Intensity Training

Intervention Type: OTHER

Interventions

High Intensity Interval Training

Intervention Type: OTHER

Moderate Intensity Training

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Ages 17-22
• Men
• BMI (25.0 - 35.0 kg/m2)
• Interested in improving health and fitness

Exclusion Criteria

• Weight loss or gain of >10% of body weight in the past 6 months for any reason.
• Currently taking medication that suppresses or stimulates appetite.
• History of prior surgical procedure for weight control or liposuction.
• Current smoker.

Any major disease, including:

• Active cancer or cancer requiring treatment in the past 2 years (except nonmelanoma skin cancer).
• Active or chronic infections, including self-reported HIV positivity and active tuberculosis.
• Diagnosed heart conditions.
• Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment.
• Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year, inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy).
• Asthma.
• Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications.

• Conditions or behaviors likely to effect the conduct of the trial: unable or unwilling to give informed consent; unable to communicate with the pertinent clinic staff; unwilling to accept treatment assignment by randomization; current or anticipated participation in another intervention research project that would interfere with the intervention offered in the trial; likely to move away from participating clinics before trial completed; unable to walk 0.25 mile in 10 minutes.
• Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months).
• Any active use of illegal or illicit drugs.
• Excessive alcohol intake defined as an average consumption of 3 or more alcohol containing beverages daily.
• Unwilling to limit alcohol intake to ≤2 drink per day (one drink = 4 oz. wine, 12 oz. beer, or ½ shot of liquor).
• Current exerciser (>30 min organized exercise per week).
• Indication of unsuitability of current health for exercise protocol (PARQ).
• Any other conditions which, in opinion of the investigators, would adversely affect the conduct of the trial.

• Minimum Eligible Age: 17 Years
• Maximum Eligible Age: 22 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

The Coca-Cola Company

INDUSTRY

Sponsor Role: collaborator

University of Alabama at Birmingham

OTHER

Sponsor Role: lead

Responsible Party

David Allison, Phd

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

UAB Physiology Lab

Birmingham, Alabama, United States

Countries

United States

References

Fisher G, Brown AW, Bohan Brown MM, Alcorn A, Noles C, Winwood L, Resuehr H, George B, Jeansonne MM, Allison DB. High Intensity Interval- vs Moderate Intensity- Training for Improving Cardiometabolic Health in Overweight or Obese Males: A Randomized Controlled Trial. PLoS One. 2015 Oct 21;10(10):e0138853. doi: 10.1371/journal.pone.0138853. eCollection 2015.

Reference Type: BACKGROUND

PMID: 26489022 (View on PubMed)

Related Links

http://www.norc.uab.edu

UAB Nutrition Obesity Research Center

Other Identifiers

F121101004

Identifier Type: -

Identifier Source: org_study_id