High-Intensity Training Following Lung Transplantation

NCT ID: NCT03155074

Last Updated: 2023-11-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

54 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-08-22

Study Completion Date

2019-01-31

Brief Summary

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The HILT study is a prospective, single-blinded, randomized controlled trial comparing a high-intensity exercise training intervention with usual care among adult lung transplant recipients. Patients randomized to the training intervention arm will undergo individually tailored high-intensity exercise training (80-95% of maximum heart rate) three hours per week for 20 weeks. Training will be conducted at local fitness centers on a one-on-one basis.

Detailed Description

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Conditions

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Lung Transplant Exercise Training

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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High-Intensity Training

Group Type EXPERIMENTAL

High-intensity training

Intervention Type BEHAVIORAL

The exercise program will include a cardiovascular warm-up, high intensity interval training and progressive resistance training (PRT). The intervention will focus on high-intensity training, mainly by uphill walking on a treadmill at 80-95 % of the maximal heart rate and PRT in three series at 6-12 RM by leg press, chest press, back extension, seat row, and front raises. During the first four weeks, the patients will be introduced to the program while focusing on safety, techniques and familiarization. The endurance intensity and strength load will then continuously increase based on the patients' improvement, tolerance of dyspnea, and feelings of well-being or fatigue on each exercise day.

Usual Care

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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High-intensity training

The exercise program will include a cardiovascular warm-up, high intensity interval training and progressive resistance training (PRT). The intervention will focus on high-intensity training, mainly by uphill walking on a treadmill at 80-95 % of the maximal heart rate and PRT in three series at 6-12 RM by leg press, chest press, back extension, seat row, and front raises. During the first four weeks, the patients will be introduced to the program while focusing on safety, techniques and familiarization. The endurance intensity and strength load will then continuously increase based on the patients' improvement, tolerance of dyspnea, and feelings of well-being or fatigue on each exercise day.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Stable medical condition in the opinion of the enrolling investigator
* Able and willing to give informed consent

Exclusion Criteria

* Expected survival less than 12 months
* Unable to complete a maximal exercise test on a treadmill until exhaustion
* Language barrier that interferes with data collection
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Norwegian School of Sport Sciences

OTHER

Sponsor Role collaborator

Oslo University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Michael Durheim

Consultant

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Elisabeth Edvardsen, PhD

Role: PRINCIPAL_INVESTIGATOR

Oslo University Hospital, Norwegian School of Sport Sciences

Michael T Durheim, MD

Role: PRINCIPAL_INVESTIGATOR

Oslo University Hospital

Locations

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Oslo University Hospital

Oslo, , Norway

Site Status

Countries

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Norway

References

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Gutierrez-Arias R, Martinez-Zapata MJ, Gaete-Mahn MC, Osorio D, Bustos L, Melo Tanner J, Hidalgo R, Seron P. Exercise training for adult lung transplant recipients. Cochrane Database Syst Rev. 2021 Jul 20;7(7):CD012307. doi: 10.1002/14651858.CD012307.pub2.

Reference Type DERIVED
PMID: 34282853 (View on PubMed)

Other Identifiers

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2017/399

Identifier Type: -

Identifier Source: org_study_id