High Intensity Interval Training After Stroke

NCT ID: NCT02550015

Last Updated: 2020-03-10

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 70 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-09-30
• Study Completion Date: 2018-12-02

Brief Summary

The purpose of this study is to examine if high intensity interval training after stroke is more effective than standard care to increase maximal oxygen uptake, reduce known risk factors for recurrent stroke and improve function.

Detailed Description

Stroke is a leading cause of adult disability. Well designed studies have shown that the majority of the stroke population have low aerobic capacity and many are inactive. This is negative for their health and well-being. Physical inactivity may increase their risk of having recurrent stroke.

The optimal training mode and intensity to improve aerobic capacity after stroke are not clear. High intensity interval training (ie. 90-95% of peak heart rate) has been proven to be more beneficial than moderate and low intensity exercise in order to improve maximal oxygen uptake in patients with cardiac disease. The response from this training on aerobic capacity and physical function in the stroke population are not known.

Conditions

Stroke

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Training

Supervised high intensity interval training (uphill treadmill walking 4 x 4 min at 90-95% of peak heart rate) 3 times weekly for 8 weeks

Group Type: EXPERIMENTAL

High intensity interval training

Intervention Type: BEHAVIORAL

Uphill treadmill walking

standard care

Standard clinical follow-up care, including general information about importance of physical activity as part of a healthy lifestyle

Group Type: OTHER

General information

Intervention Type: BEHAVIORAL

Standard care

Interventions

High intensity interval training

Uphill treadmill walking

Intervention Type: BEHAVIORAL

General information

Standard care

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Approved informed consent
• Independent walking > 2 minutes
• First episode of stroke (ischemic or hemorrhagic)
• Minimum 3 months post-stroke
• Living in the community and able to travel to assessment and training site
• Approval to participate from the study's responsible medical doctor
• Modified Rankin Scale 0-3

Exclusion Criteria

• Impaired cognitive function to give valid informed consent to participate
• Instability of cardiac conditions (ie. serious rhythm disorder, valve malfunction)
• Other conditions where test of maximal oxygen uptake is contraindicated
• Poorly controlled hypertension (>180/100), measured at rest
• > 5 years post stroke
• Subarachnoid hemorrhage
• Participating in other ongoing intervention study
• Other serious illness influencing testing of cardiorespiratory fitness and function at 1 year follow-up

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Norwegian University of Science and Technology

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Torunn Askim, phd

Role: STUDY_DIRECTOR

Norwegian University of Science and Technology

Locations

Department of Neuroscience

Trondheim, , Norway

Countries

Norway

References

Gjellesvik TI, Becker F, Tjonna AE, Indredavik B, Nilsen H, Brurok B, Torhaug T, Busuladzic M, Lydersen S, Askim T. Effects of High-Intensity Interval Training After Stroke (the HIIT-Stroke Study): A Multicenter Randomized Controlled Trial. Arch Phys Med Rehabil. 2020 Jun;101(6):939-947. doi: 10.1016/j.apmr.2020.02.006. Epub 2020 Mar 4.

Reference Type: RESULT

PMID: 32145280 (View on PubMed)

Other Identifiers

2015/563

Identifier Type: -

Identifier Source: org_study_id