Effects of Different Aerobic Exercise Programs With Nutritional Interventions in Hypertensive and Overweight People

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

176 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-31

Study Completion Date

2017-01-31

Brief Summary

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Obesity and arterial hypertension (HTN) frequently coexist in the same patient. Moreover, the concept that obesity and HTN can be additive in terms of cardiovascular rist is widely accepted. Yet, clinical decision-making in obese patients is complicated by a surprising lack of evidence on the relative importance of obesity and HTN treatment and its efficacy and safety. Lifestyle interventions are the mainstay of obesity management programs and are also advocated in the prevention and treatment of HTN. Physical exercise and diet are recommended to prevent and control obesity and HTN. Aerobic exercise is firmly established as an effective measure for lowering blood pressure and reducing cardiovascular risk. However, there is no agreement about the optimal dose of frequency, intensity, duration and type of exercise. Therefore, the aims of the study are: 1) to assess the changes in selected parameters of blood pressure, cardiorespiratory fitness, body composition and biological markers brought about by a period of 16-week of different aerobic exercise programs with hypocaloric diet for overweight or obesity and primary hypertensive adults, and 2) to examine the effect of six months detraining subsequent to intervention. Secondary objectives are to examine the additional effect of the intervention on physical activity behavior and health-related quality of life.

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Detailed Description

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METHODOLOGY: participants will perform a ramp incremental cardiopulmonary exercise bike test before, after 16-week of follow-up, and after 6-month detraining period (with no intervention only recommendations). After inclusion criteria they will be randomized to four parallel groups: 1) control group with only hypocaloric diet intervention and lifestyle recommendations; 2) Moderate (HR values between VT1 and VT2 or 50-75% of HR reserve) continuous exercise and high volume (from 20 to 45min) group and hypocaloric diet intervention; 3) high intensity (HR values up to VT2 to peak intensity or ≥76% to \<100 % of HR reserve) interval training and high-volume (from 20 to 45min) group alternating high and moderate intensities at different protocols and hypocaloric diet intervention; and 4) high-intensity interval training and low-volume (20min) group alternating high and moderate intensities at different protocolsand hypocaloric diet intervention.

Conditions

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Hypertension Overweight Sedentary

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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CONTROL GROUP-DIET

Hypocaloric diet intervention with no supervised exercise intervention

Group Type ACTIVE_COMPARATOR

DIET

Intervention Type BEHAVIORAL

Lifestyle intervention through hypocaloric diet

DIET & MODERATE CONTINUOUS TRAINING

Intervention with hypocaloric diet and supervised moderate continuous exercise training (60-80%HRpeak). High volume training (45 minutes in progression from 20 min)

Group Type EXPERIMENTAL

DIET & MODERATE CONTINUOUS TRAINING

Intervention Type BEHAVIORAL

Lifestyle intervention through hypocaloric diet and exercise at moderate intensity (60-80%peakHR) continuous mode, and high volume (45 min).

DIET & HIGH VOLUME HIIT

Intervention with hypocaloric diet and supervised high intensity interval training (85-95%HRpeak). High volume training (45 minutes in progression from 20 min)

Group Type EXPERIMENTAL

DIET & HIGH VOLUME HIIT

Intervention Type BEHAVIORAL

Lifestyle intervention through hypocaloric diet and exercise at high intensity (80-95%peakHR) interval mode, and high volume (45 min).

DIET & LOW VOLUME HIIT

Intervention with hypocaloric diet and supervised high intensity interval training (85-95%HRpeak). Low volume training (20 min)

Group Type EXPERIMENTAL

DIET & LOW VOLUME HIIT

Intervention Type BEHAVIORAL

Lifestyle intervention through diet and exercise at high intensity (80-95%peakHR) interval mode, and low volume (20 min).

Interventions

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DIET

Lifestyle intervention through hypocaloric diet

Intervention Type BEHAVIORAL

DIET & MODERATE CONTINUOUS TRAINING

Lifestyle intervention through hypocaloric diet and exercise at moderate intensity (60-80%peakHR) continuous mode, and high volume (45 min).

Intervention Type BEHAVIORAL

DIET & HIGH VOLUME HIIT

Lifestyle intervention through hypocaloric diet and exercise at high intensity (80-95%peakHR) interval mode, and high volume (45 min).

Intervention Type BEHAVIORAL

DIET & LOW VOLUME HIIT

Lifestyle intervention through diet and exercise at high intensity (80-95%peakHR) interval mode, and low volume (20 min).

Intervention Type BEHAVIORAL

Other Intervention Names

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CONTROL GROUP MCT HV-HIIT LV-HIIT

Eligibility Criteria

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Inclusion Criteria

* older than 18yr old and less than 70yr old
* overweight (BMI \>25)
* primary hypertension
* low-moderate cardiovascular risk
* not diet treatment
* sedentary behavior
* availability to exercise two days a week.

Exclusion Criteria

* secondary hypertension
* pulmonary disorder
* neurological deficit
* physical incapacity to exercise
* to exercise frequently
* pregnancy or breastfeeding
* left ventricular hypertrophy
* more than three cardiovascular risk factors

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No