The Link Between Physical Activity and Brain Health in Healthy Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-11-25

Study Completion Date

2026-09-30

Brief Summary

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The goal of this observational study is to investigate the cross-sectional relationship between physical activity and brain health from a multiscale approach (neuropsychology, neuroimaging, peripheral biomarkers and genetics) in former athletes and sedentary individuals. The main question it aims to answer is:

Do former athletes have better brain structure than sedentary people? Evaluating the differences in neurodegenerative processes between competitive training and sedentary and inactivity.

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Detailed Description

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Conditions

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Alzheimer Disease Inactivity Preventive Therapy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Ex-athletes and continue to exercise regularly

No interventions assigned to this group

Sedentary individuals

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Group A: ex-athletes and continue to perform regular physical exercise (minimum 3 days/week of moderate-vigorous intensity).
* Group B: sedentary individuals, (i.e., perform \<150 min of moderate intensity exercise per week or IPAQ score\<600 MET min/week).
* In both groups (A and B) the conditions of physical exercise or sedentary lifestyle must have been maintained for at least 6 months prior to the evaluations.
* Not having a history of neurological or psychiatric disorder or suffering from a serious medical condition

Exclusion Criteria

* Medical conditions that have a high risk of associated cognitive symptoms.
* Severe head injury with loss of consciousness within the previous 5 years.
* Alcoholism (\>3 alcoholic drinks per day).
* Chronic use of anxiolytics, neuroleptics, narcotics, anticonvulsants, or sedative hypnotics.
* Hearing or visual impairment that would preclude testing
* History of neurological disease with clinically relevant impact on cognition (e.g. cerebrovascular disease).
* Incidental structural brain findings with impact on cognitive impairment or survival (e.g., malignant brain tumor).
* Presence of severe systemic disease (e.g., cancer under treatment).
* Consumption of anabolic substances.
* Problems understanding spoken or written Spanish.
* Those with pacemakers or metallic implants that may interfere with the MRI.

Minimum Eligible Age

40 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes