Physical Fitness and Hot Executive Function in Alzheimer's Risk
NCT ID: NCT07081269
Last Updated: 2025-07-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
240 participants
OBSERVATIONAL
2025-01-10
2027-07-31
Brief Summary
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Detailed Description
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Assessment Protocol: Participants complete comprehensive evaluations at baseline and 18-month follow-up, including: (1) cardiorespiratory fitness via YMCA submaximal cycle ergometry; (2) muscular strength through one-repetition maximum testing (chest press, leg press); and (3) executive function using computerized task-switching paradigms with simultaneous electroencephalography. Secondary measures include demographics (age, sex, education), physical activity levels (International Physical Activity Questionnaire-Taiwan Short Form), global cognition (Mini-Mental State Examination), and working memory (digit span forward/backward). Additionally, Apolipoprotein E ε4 (APOE ε4) genotype will be examined as a potential moderator of fitness-cognition relationships.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Older adults
Older adults, 50-70 years old.
observation alone
No interventions will be conducted during the observation period, maintaining participants' normal daily living conditions.
Interventions
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observation alone
No interventions will be conducted during the observation period, maintaining participants' normal daily living conditions.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Able to engage in fitness testing.
* Normal vision or corrected-to-normal vision.
Exclusion Criteria
* Suffering from cognitive, neurological or psychiatric disorders (e.g., dementia, Parkinson's disease, epilepsy, depression, schizophrenia, etc.).
* Suffering from infectious diseases (e.g., hepatitis, human immunodeficiency virus or Creutzfeldt-Jakob disease).
* Having a history of drug or alcohol abuse.
* Having colour vision deficiency (e.g., colour blindness).
* Having a family history of aneurysm.
* Taking medications that affect brain function.
50 Years
70 Years
ALL
Yes
Sponsors
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National Taiwan Normal University
OTHER
Responsible Party
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Yu-Kai Chang
Principal Investigator
Principal Investigators
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Yu-Kai Chang, PhD
Role: STUDY_DIRECTOR
National Taiwan Normal University
Chine-Heng Chu, PhD
Role: PRINCIPAL_INVESTIGATOR
National Taiwan Normal University
Locations
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National Taiwan Normal University
Taipei, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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PACNL_HPF_HEF
Identifier Type: -
Identifier Source: org_study_id
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