Exercise and Neurocognition in Adults Relative to ApoE Genotype
NCT ID: NCT05101174
Last Updated: 2023-11-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
120 participants
INTERVENTIONAL
2022-04-11
2025-09-30
Brief Summary
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Detailed Description
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The study will randomly assign 100 eligible participants to either the IIP group or the control group in a 1:1 ratio. The IIP group will engage in 150 min of exercise per week, which consists of one 90-min on-site session and multiple online sessions, for 6 months. The control group will be invited to attend one 60-minutes online educational course per week for 6 months.
The neurocognitive function, the components of ERP, ApoE genotype, physical fitness, and BDNF will be assessed at the baseline (Baseline-Assessment) and the end of the 6-month intervention (Post-Assessment).
Conditions
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Study Design
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RANDOMIZED
PARALLEL
HEALTH_SERVICES_RESEARCH
SINGLE
Study Groups
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Integrated Intervention Group (IIG)
The IIG attends 150 min exercise per week, which consists of one 90-min trainer-supervised program and multiple online sessions, for 6 months.
Intervention: aerobic exercise, resistance exercise, coordinative exercise, flexibility, social interaction, and meditation.
Integrated Intervention Group (IIG)
The IIG attends 150 min exercise per week, which consists of one 90-min trainer-supervised session and multiple online sessions for 6 months. Each session consists of (1) warm-up, (2) resistance exercise and flexibility exercise, (3) resistance exercise and coordinative exercise from the "Eastern exercise" perspective, (4) social interaction exercise, and (5) cool-down and meditation.
Control Group
The control group is invited to attend one 60-min online educational course per week for 6 months.
Intervention: 60-min online educational program.
Control Group
The Control Group is informed to maintain their lifestyles and invited to attend one 60-min online educational course per week. The participants are required to provide their physical activity behavior once every month for 6 months (6 times).
Interventions
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Integrated Intervention Group (IIG)
The IIG attends 150 min exercise per week, which consists of one 90-min trainer-supervised session and multiple online sessions for 6 months. Each session consists of (1) warm-up, (2) resistance exercise and flexibility exercise, (3) resistance exercise and coordinative exercise from the "Eastern exercise" perspective, (4) social interaction exercise, and (5) cool-down and meditation.
Control Group
The Control Group is informed to maintain their lifestyles and invited to attend one 60-min online educational course per week. The participants are required to provide their physical activity behavior once every month for 6 months (6 times).
Eligibility Criteria
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Inclusion Criteria
* Able to speak and read Chinese
* Scores of Mini-Mental Status Examination \>= 25
* Physical Activity Readiness Questionnaire score \< 0
* Able to conduct the exercise with moderate intensity
* Provide informed consent
Exclusion Criteria
* Diagnosed or self-reported physical disease (e.g., untreated hypertension and chronic heart disease, stroke, brain tumor, musculoskeletal disorders, other exercise contradictions)
* Diagnosed or self-reported major psychiatric illness (e.g., major depression, schizophrenia)
* Diagnosed or self-reported neurodegenerative disease (e.g., Alzheimer's disease or other dementias, Parkinson's disease (PD) and PD-related disorders, Huntington's disease)
* History of alcohol or drug abuse
* History of chemotherapy
* Traveling consecutively for three weeks or more during the study
* Unwillingness to be randomized to one of the two groups
* Currently participating in another study trial
45 Years
70 Years
ALL
Yes
Sponsors
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National Taiwan Normal University
OTHER
Responsible Party
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Yu-Kai Chang
Professor
Principal Investigators
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Yu-Kai Chang, PhD
Role: PRINCIPAL_INVESTIGATOR
Department of Physical Education and Sport Sciences, National Taiwan Normal University
Locations
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Yu-Kai Chang
Taipei, , Taiwan
Yu-Kai Normal Chang
Taipei, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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PACNL_IIP and Neurocog_ERP
Identifier Type: -
Identifier Source: org_study_id