The Therapeutic Effect of Exercise Training on Patients With Dementia and Mild Cognitive Impairment

NCT ID: NCT03811314

Last Updated: 2024-02-28

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 107 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-04-09
• Study Completion Date: 2023-12-26

Brief Summary

This study aimed to clarify whether strength training or aerobic training could bring more benefits for patients with dementia, another study is to clarify whether isokinetic or isotonic training could bring more benefits for patients with mild cognitive impairment

Detailed Description

Exercise training has been evidenced to bring various of benefits for patients with dementia in past studies. However, whether strength training or aerobic training could bring better benefits has not been confirmed in the past. This study designed to recruit 30 patients with mild dementia in the first year. Every patient will receive strength training using dumbbells, butterfly machine and vertical leg press machine for four weeks. Outcome measures including self care ability, cognitive function, MCP-1, BDNF and IGF-1 levels, and the degree of depression will be recorded before and after the training. In the second year, the investigators also designed to recruit 31 patients with mild dementia. These participants will instead receive aerobic training using stationary bicycle for four weeks. The same outcome measures will be tested as in the first year. The other part of the study recruited 46 patients with mild cognitive impairment, who were randomized into either a four-week isokinetic or isotonic training program. All cases were evaluated by isokinetic peak torque, 36-item Short Form Survey (SF-36), Mini-Mental State Examination (MMSE), Barthel Index, geriatric depression scale (GDS-15), and Timed Up and Go test (TUG test) before and after each kind of training.

Conditions

Dementia

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Strength training

Muscle strength training programs

Group Type: EXPERIMENTAL

Strength training

Intervention Type: DEVICE

Using dumbbells, butterfly machine and vertical leg press machine for strength training, 12 repetition maximum weight for 12 repetition, three times a day, five days a week, for a total of four weeks

Aerobic training

Aerobic training programs

Group Type: EXPERIMENTAL

Aerobic training

Intervention Type: DEVICE

Using stationary bicycle to perform cardiopulmonary endurance training in 50-70 heart rate reserve for 20 minutes, five days per week, for a total of four weeks

Isokinetic training

Isokinetic training

Group Type: EXPERIMENTAL

Isokinetic trinaing

Intervention Type: DEVICE

Using Biodex isokinetic dynanometer and set it in isokinetic mode in 60 degree per second

Isotonic training

Isotonic training

Group Type: EXPERIMENTAL

Isotonic training

Intervention Type: DEVICE

Using Biodex isokinetic dynanometer and set it in isotonic mode at 60% of the maximal peak torque

Interventions

Strength training

Using dumbbells, butterfly machine and vertical leg press machine for strength training, 12 repetition maximum weight for 12 repetition, three times a day, five days a week, for a total of four weeks

Intervention Type: DEVICE

Aerobic training

Using stationary bicycle to perform cardiopulmonary endurance training in 50-70 heart rate reserve for 20 minutes, five days per week, for a total of four weeks

Intervention Type: DEVICE

Isokinetic trinaing

Using Biodex isokinetic dynanometer and set it in isokinetic mode in 60 degree per second

Intervention Type: DEVICE

Isotonic training

Using Biodex isokinetic dynanometer and set it in isotonic mode at 60% of the maximal peak torque

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

1. Patients aged above 65 years old

2. Patients with mild dementia with Mini-mental state examination scoring 15 to 26

3. Another arm is patients with mild cognitive impairment and Mini-mental state examination scoring 23 to 27

Exclusion Criteria

1. Cardiopulmonary diseases or orthopedical conditions that prohibit the patient from receiving exercise training of our programs

2. Cognitive problems that impede the patient to understand and answer the content of our questionnaires.

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Taichung Veterans General Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Yuan-Yang Cheng, MDPHD

Role: PRINCIPAL_INVESTIGATOR

Department of rehabilitation of Taichung Veterans General Hospital

Locations

Taichung Veterans General Hospital

Taichung, , Taiwan

Countries

Taiwan

References

Liu IT, Lee WJ, Lin SY, Chang ST, Kao CL, Cheng YY. Therapeutic Effects of Exercise Training on Elderly Patients With Dementia: A Randomized Controlled Trial. Arch Phys Med Rehabil. 2020 May;101(5):762-769. doi: 10.1016/j.apmr.2020.01.012. Epub 2020 Feb 19.

Reference Type: DERIVED

PMID: 32084347 (View on PubMed)

Other Identifiers

CF18010B

Identifier Type: -

Identifier Source: org_study_id