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Exercise as a Modulator of Immune Risk Factors for Ischemic Heart Disease

NCT ID: NCT04195932

Last Updated: 2019-12-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

52 participants

Study Classification

INTERVENTIONAL

Study Start Date

1996-12-31

Study Completion Date

1998-05-31

Brief Summary

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A before and after study involving 43 adult subjects at risk of having ischemic heart disease. Subjects underwent 6 months of supervised moderate intensity aerobic and resistive exercise training. Blood samples were obtained at entry and at 6 months for measurement of complement (C3), CRP, blood lipid levels, lymphocyte phenotypes, and for the isolation, culture, and measurement of the spontaneous and phytohemagglutinin-induced secretion of proatherogenic and antiatherogenic cytokines by their peripheral blood mononuclear cells (PBMC).

Detailed Description

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A before and after study involving 43 adult subjects at risk of having ischemic heart disease. Subjects underwent 6 months of supervised moderate intensity aerobic and resistive exercise training. Blood samples were obtained at entry and at 6 months for measurement of complement (C3), CRP, blood lipid levels, lymphocyte phenotypes, and for the isolation, culture, and measurement of the spontaneous and phytohemagglutinin-induced secretion of proatherogenic and antiatherogenic cytokines by their peripheral blood mononuclear cells (PBMC

Conditions

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Heart Diseases

Keywords

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exercise hyperlipidemia TNF-alpha atherogenesis LDL-cholesterol oxidized LDL-C

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Before and after study
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Exercise

6 moths of supervised moderate intensity aerobic and resistive exercise training

Group Type EXPERIMENTAL

Exercise training

Intervention Type OTHER

Interventions

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Exercise training

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* normal EKG
* normal stress test

Exclusion Criteria

* abnormal EKG
* abnormal stress test
* presence of a chronic inflammatory disease
* presence of malignancy
* immunosuppressive therapy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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East Tennessee State University

OTHER

Sponsor Role lead

Responsible Party

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John Kelly Smith

Emeritus Professor of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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John K Smith, MD

Role: PRINCIPAL_INVESTIGATOR

East Tennessee State University

Locations

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James H. Quillen College of Medicine

Johnson City, Tennessee, United States

Site Status

Countries

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United States

Other Identifiers

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ETSU2

Identifier Type: -

Identifier Source: org_study_id