The Impact of Ischemic Preconditioning on Exercise Performance and Physiological Function

NCT ID: NCT07146399

Last Updated: 2025-08-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-31

Study Completion Date

2024-02-07

Brief Summary

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Ischemic Preconditioning has been confirmed to prevent long-term ischemic damage to tissues, among which the improvement of autonomic nerve system function may be one of its mechanisms of action. In recent years, IPC has gradually been applied to enhance athletic performance and accelerate postexercise recovery; however, there has been limited research on the effects of IPC on ANS function and competitive condition before and after exercise. This study investigated the effects of IPC on ANS function before and after sport-specific testing in taekwondo athletes. The objectives of our study are (1) to investigate the impact of IPC on two indicators of autonomic nervous function-HRV and HRR-and (2) to reveal the coordinating effect of IPC on the sympathetic and parasympathetic nervous systems during the warm-up phase and after specific testing in taekwondo athletes. The investigators hypothesize that IPC enhances sympathetic drive during the warm-up phase and rapidly activates the parasympathetic nervous system postexercise, which is accompanied by improvements in the athletes' competitive condition.

Detailed Description

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Conditions

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Ischemic Preconditioning Autonomic Nervous System (ANS) Functioning and Mood State

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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IPC Trial

220 mmHg

Group Type EXPERIMENTAL

Ischemic Preconditioning

Intervention Type PROCEDURE

Compression cuff width: 10CM; Compression duration: 5min/5min (ischemia/reperfusion) \*4. 220 mmHg

SHAM Trial

20 mmHg

Group Type PLACEBO_COMPARATOR

Sham (No Treatment)

Intervention Type PROCEDURE

Compression cuff width: 10CM; Compression duration: 5min/5min (compression/relaxation) \*4. 20 mmHg

Interventions

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Ischemic Preconditioning

Compression cuff width: 10CM; Compression duration: 5min/5min (ischemia/reperfusion) \*4. 220 mmHg

Intervention Type PROCEDURE

Sham (No Treatment)

Compression cuff width: 10CM; Compression duration: 5min/5min (compression/relaxation) \*4. 20 mmHg

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Taekwondo athletes with a national ranking of level two or higher, including those placed in the top three at the Provincial Professional Taekwondo Championship (combat) and the top eight at the National Professional Taekwondo Championship (combat);
* adult males aged 18 years or older;
* regular participation in specialized Taekwondo training for the past three months.
* All the subjects were from the same team.

Exclusion Criteria

* consumption of alcohol or caffeine within 24 hours prior to the experiment;
* engagement in strenuous physical activity within 24 hours before the experiment;
* presence of acute or chronic diseases, including cardiovascular diseases, anxiety disorders, and metabolic diseases;
* use of creatine supplements
Minimum Eligible Age

18 Years

Maximum Eligible Age

22 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Guangzhou Sport University

OTHER

Sponsor Role collaborator

Ziyue Ou

OTHER

Sponsor Role lead

Responsible Party

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Ziyue Ou

Sponsor-Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Guangzhou Sport University

Guangzhou, Guangdong, China

Site Status

Countries

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China

References

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Tsutsui H, Tanaka R, Yamagata M, Yukimura T, Ohkita M, Matsumura Y. Protective effect of ischemic preconditioning on ischemia/reperfusion-induced acute kidney injury through sympathetic nervous system in rats. Eur J Pharmacol. 2013 Oct 15;718(1-3):206-12. doi: 10.1016/j.ejphar.2013.08.032. Epub 2013 Sep 12.

Reference Type BACKGROUND
PMID: 24036256 (View on PubMed)

Lopes TR, Sabino-Carvalho JL, Ferreira THN, Succi JE, Silva AC, Silva BM. Effect of Ischemic Preconditioning on the Recovery of Cardiac Autonomic Control From Repeated Sprint Exercise. Front Physiol. 2018 Oct 26;9:1465. doi: 10.3389/fphys.2018.01465. eCollection 2018.

Reference Type BACKGROUND
PMID: 30416451 (View on PubMed)

Noronha Osorio D, Viana-Soares R, Marto JP, Mendonca MD, Silva HP, Quaresma C, Viana-Baptista M, Gamboa H, Vieira HLA. Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment. BMC Cardiovasc Disord. 2019 Sep 9;19(1):211. doi: 10.1186/s12872-019-1181-5.

Reference Type BACKGROUND
PMID: 31500561 (View on PubMed)

Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986 Nov;74(5):1124-36. doi: 10.1161/01.cir.74.5.1124.

Reference Type BACKGROUND
PMID: 3769170 (View on PubMed)

Other Identifiers

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2023LCLL-81

Identifier Type: -

Identifier Source: org_study_id

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