Strength Training Induced Alterations in Markers of Immune Function
NCT ID: NCT01450852
Last Updated: 2011-10-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
42 participants
INTERVENTIONAL
2010-01-31
2010-05-31
Brief Summary
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Preliminary data suggest that MC3R gene expression increases in whole blood after chronic exercise training. The primary aim of the current study is to explore whether this change in gene expression translates into alterations in MC1R, MC3R, or MC5R monocyte surface expression. The secondary aim is to examine the relationship between surface expression of these receptors and circulating inflammatory profiles.
The investigators will recruit 42 untrained, healthy males and females aged 18-35 yrs. Half of the group will be placed on an exercise program for 15 weeks. The other half will serve as untrained control subjects. In addition to basic anthropometric measures, the investigators will measure concentrations of inflammatory and anti-inflammatory cytokines (ELISA) and cell surface expression of MC1R, MC3R, and MC5R on monocytes (flow cytometry).
Detailed Description
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Chronic exercise reduces inflammation, but the mechanisms involved are unclear. Recent studies have shown that stimulation of melanocortin 1 and 3 receptors (MC1R and MC3R) on immune cells increases anti-inflammatory cytokine production. PURPOSE: To examine the influence of 12 weeks of resistance training (RT) on body composition, monocyte cell-surface expression of MC1R and MC3R and circulating markers of inflammation. METHODS: Healthy, active males and females (age 20-27 yr) were recruited into a RT group (RE; n = 23) and an active control group (AC; n = 19). RE completed 12 weeks of progressive, periodized RT 3d/wk while AC maintained normal activity habits. Measures of body composition (DXA) were taken and blood was collected prior to (PRE) and following the intervention period (POST). Blood samples were analyzed for monocyte cell-surface expression MC1R, MC3R, MC5R and C-reactive protein (CRP) and the plasma cytokines interleukin 6 (IL-6) and interleukin 10 (IL-10) using flow cytometry and ELISAs respectively.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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Strength Training
The strength training group completed 12 weeks of progressive, periodized resistance training 3d/wk.
Strength Training
Each Member of this group completed 12 weeks of progressive, periodized resistance training for 3d/wk.
Active Control Group
The active control group was instructed to maintain normal activity and eating habits. They participated in all pre and post intervention measures.
No interventions assigned to this group
Interventions
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Strength Training
Each Member of this group completed 12 weeks of progressive, periodized resistance training for 3d/wk.
Eligibility Criteria
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Inclusion Criteria
* The Strength Training Group Members Must Be Approved For Participation by a Licensed MD
Exclusion Criteria
* Unhealthy participants (those with existing conditions)
18 Years
30 Years
ALL
Yes
Sponsors
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Louisiana State University Health Sciences Center in New Orleans
OTHER
Responsible Party
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Laura Stewart
Assistant Professor
Principal Investigators
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Laura K Stewart, PhD
Role: PRINCIPAL_INVESTIGATOR
Louisiana State University Health Sciences Center in New Orleans
Locations
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Louisiana State University
Baton Rouge, Louisiana, United States
Countries
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References
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Henagan TM, Forney L, Dietrich MA, Harrell BR, Stewart LK. Melanocortin receptor expression is associated with reduced CRP in response to resistance training. J Appl Physiol (1985). 2012 Aug;113(3):393-400. doi: 10.1152/japplphysiol.00107.2012. Epub 2012 Jun 7.
Other Identifiers
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LSU-IRB # 3005
Identifier Type: -
Identifier Source: org_study_id