Eccentric Cycling Exercise With Assistive Devices on Mitochondrial Metabolism in T Lymphocyte

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-23

Study Completion Date

2024-12-31

Brief Summary

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Eccentric cycling exercise can be a promising modality fwith lower respiratory demands and higher power output. Assistive devices like neuromuscular electrical stimulation (NMES) and compressive garment (CG) accelerates muscle pumping and relieve the eccentric exercise-induced muscle soreness.

Phenotypes and mitochondrial metabolism are crucial to regulate acquired immnunity of T lymphocytes. The study aimed to investigate the effects of eccentric cycling exercise training combined with NMES and CG on mitochondrial phenotypes and bioenergetics in T lymphocytes in sedentary males. The hypothesis were an acute/intense exercise decreased the mitochondrial respiratory capacities of OXPHOS, ETS and bioenergetics, while eccentric cycling training could elevate the diminished mitochondrial functions.

Methods: Twelve sedentary healthy males were randomly assigned to either eccentric cycling with assistive devices (ECA, n=10) or eccentric cycling only (ECC, n=10). All participants performed ECA or ECC at an intensity of 60% to 120% maximal workload progressively on a costumed bicycle ergometer for 40 min/day, 5 days/week for 5 weeks. ECA performed NMES for 20min/session after cycling, while ECC was seated for resting 20 min. Systemic aerobic fitness, phenotypes of T lymphocytes, mitochondrial OXPHOS, ETS respiratory capacities, and bioenergetics in T lymphocytes were analyzed.

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Detailed Description

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Conditions

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There Are no Conditions Under Study. Healthy Volunteers

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Eccentric cycling exercise (ECC)

High intensity cycling training from 80% to 120% Wmax in eccentric type

Group Type EXPERIMENTAL

Eccentric cycling exercise (ECC)

Intervention Type BEHAVIORAL

Performed exercise training 5 days a week for 5 weeks on an eccentric ergometer.

Each training session: 5 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase.

After each training session, rest in sitting position for 20 min. Exercise intensity: Firstly, set at 80% Wmax, and progressively increased 5% per week to 120 % Wmax in the last week.

Eccentric cycling exercise with assistive devices (ECA)

High intensity cycling training from 80% to 120% Wmax in eccentric type (intensity matched the ECC)

Group Type EXPERIMENTAL

Eccentric cycling exercise with assistive devices (ECA)

Intervention Type BEHAVIORAL

Performed exercise training 5 days a week for 5 weeks on an eccentric ergometer.

Each training session: 5 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase.

After each training session, receive NMES in sitting position for 20 min.

Intensity: Firstly, set at 80% Wmax, and progressively increased 5% per week to 120 % Wmax in the last week.

Control group

Perform no exercise training but maintain only regular daily lives only in the study.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Eccentric cycling exercise (ECC)

Performed exercise training 5 days a week for 5 weeks on an eccentric ergometer.

Each training session: 5 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase.

After each training session, rest in sitting position for 20 min. Exercise intensity: Firstly, set at 80% Wmax, and progressively increased 5% per week to 120 % Wmax in the last week.

Intervention Type BEHAVIORAL

Eccentric cycling exercise with assistive devices (ECA)

Performed exercise training 5 days a week for 5 weeks on an eccentric ergometer.

Each training session: 5 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase.

After each training session, receive NMES in sitting position for 20 min.

Intensity: Firstly, set at 80% Wmax, and progressively increased 5% per week to 120 % Wmax in the last week.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Sedentary lifestyle (exercise\<20min/session; \<1session/week for a year or longer).
* Nonsmokers, nonusers of medications/vitamins.
* No any cardiopulmonary, neuromuscular, and hematological risks.