Eccentric Cycling Exercise on Mitochondrial Function of Lymphocyte
NCT ID: NCT06576804
Last Updated: 2024-08-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
33 participants
INTERVENTIONAL
2021-01-01
2022-08-01
Brief Summary
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Method: A total of 33 healthy sedentary males were randomized and divided into ECE (n=11), CCE (n=11), and control groups (n=11). These subjects progressively performed CCE or ECE from 60% to 80% maximal workload on a bicycle ergometer for 40 min/day, 5 days/week for 6 weeks. A graded exercise testing and an isokinetic strength test were conducted to evaluate cardiopulmonary fitness and muscle strength, respectively. Phenotypes and mitochondrial respiratory capacity in T lymphocyte were analyzed using flow cytometry and high-resolution respirometer, respectively.
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Detailed Description
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Mitochondria of lymphocytes are essential for cell proliferation, death, and differentiation, and play a critical role in establishing lymphocyte phenotypes and their functions.
Whether EET influences lymphocyte bioenergetic efficiency remains unclear. The study was to investigate the effects of ECE and CCE regimens on adaptive immune functions and mitochondrial bioenergetics of T lymphocytes in sedentary males.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Eccentric cycling training
Moderate to high intensity cycling training in eccentric type
Eccentric cycling training
Performed exercise training 5 days a week for 6 weeks on an eccentric ergometer.
Each training session: 5 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase.
Intensity: Firstly, set at 60% Wmax, and progressively increased 5% per week
Concentric cycling training
Moderate to high intensity cycling training in concentric type (intensity matched the eccentric training)
Concentric cycling training
Performed exercise training 5 days a week for 6 weeks on an eccentric ergometer.
Each training session: 5 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase.
Intensity: Firstly, set at 60% Wmax, and progressively increased 5% per week
Control group
without receiving any exercise training
No interventions assigned to this group
Interventions
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Eccentric cycling training
Performed exercise training 5 days a week for 6 weeks on an eccentric ergometer.
Each training session: 5 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase.
Intensity: Firstly, set at 60% Wmax, and progressively increased 5% per week
Concentric cycling training
Performed exercise training 5 days a week for 6 weeks on an eccentric ergometer.
Each training session: 5 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase.
Intensity: Firstly, set at 60% Wmax, and progressively increased 5% per week
Eligibility Criteria
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Inclusion Criteria
2. Nonsmokers, nonusers of medications/vitamins.
3. No any cardiopulmonary/hematological risks.
Exclusion Criteria
2. Have retabolic or musculoskeletal disease.
20 Years
30 Years
MALE
Yes
Sponsors
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Chang Gung Memorial Hospital
OTHER
Responsible Party
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Jong-Shyan Wang
Principal Investigator
Locations
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Chang Gung University
Taoyuan District, , Taiwan
Countries
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References
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LaStayo PC, Ewy GA, Pierotti DD, Johns RK, Lindstedt S. The positive effects of negative work: increased muscle strength and decreased fall risk in a frail elderly population. J Gerontol A Biol Sci Med Sci. 2003 May;58(5):M419-24. doi: 10.1093/gerona/58.5.m419.
Hody S, Croisier JL, Bury T, Rogister B, Leprince P. Eccentric Muscle Contractions: Risks and Benefits. Front Physiol. 2019 May 3;10:536. doi: 10.3389/fphys.2019.00536. eCollection 2019.
Touron J, Costes F, Coudeyre E, Perrault H, Richard R. Aerobic Metabolic Adaptations in Endurance Eccentric Exercise and Training: From Whole Body to Mitochondria. Front Physiol. 2021 Jan 27;11:596351. doi: 10.3389/fphys.2020.596351. eCollection 2020.
Tsai HH, Chang SC, Chou CH, Weng TP, Hsu CC, Wang JS. Exercise Training Alleviates Hypoxia-induced Mitochondrial Dysfunction in the Lymphocytes of Sedentary Males. Sci Rep. 2016 Oct 12;6:35170. doi: 10.1038/srep35170.
Other Identifiers
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202100004A3
Identifier Type: -
Identifier Source: org_study_id
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