Eccentric Cycling Exercise on Hemodynamic and Hemorheologic Properties
NCT ID: NCT04773444
Last Updated: 2021-05-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2019-11-11
2022-05-16
Brief Summary
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Method: A total of 39 sedentary males were randomly assigned into either CCT (n=13) or ECT (n=13) for 30 min a day, 5 days a week for 6 weeks at 60% of maximal workload or to a CTL (control group, n = 13). A graded exercise test (GXT) was performed before and after the intervention. Central and microvascular adaptations were evaluated using thoracic impedance and near-infrared spectroscopy (NIRS), respectively. Rheological characteristics was determined by an ektacytometer.
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Detailed Description
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Erythrocytes deformability is significantly related to the blood perfusion in microcirculation. The impaired erythrocyte-related rheology further lead to reduced aerobic capacity by our research team. Therefore, the lower energy consumed in ECT may avoid the oxidative stress. To now, less studies have demonstrated whether ECT influences peripheral hemodynamics by erythrocyte rheology and the blood flow from the central effect.
The investigators aimed to investigate the effects of CCT and ECT on oxygen consumption response explained by changes in local blood perfusion, blood cell rheology, or central function to attempt developing its application in rehabilitation.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Eccentric cycling training
Moderate intensity cycling training in eccentric type
Eccentric cycling training
1. Performed exercise training 5 days a week for 6 weeks on an eccentric ergometer.
2. Each training session: 3 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase.
3. Intensity: Firstly, set at 45% Wmax, and progressively increased 5% per week
Concentric cycling training
Moderate intensity cycling training in concentric type (intensity matched the eccentric training)
Concentric cycling training
1. Performed exercise training 5 days a week for 6 weeks on an eccentric ergometer.
2. Each training session: 3 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase.
3. Intensity: Firstly, set at 45% Wmax, and progressively increased 5% per week
Control group
without receiving any exercise training
No interventions assigned to this group
Interventions
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Eccentric cycling training
1. Performed exercise training 5 days a week for 6 weeks on an eccentric ergometer.
2. Each training session: 3 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase.
3. Intensity: Firstly, set at 45% Wmax, and progressively increased 5% per week
Concentric cycling training
1. Performed exercise training 5 days a week for 6 weeks on an eccentric ergometer.
2. Each training session: 3 min at 30% of maximal workload (Wmax) for warmed up and cold down and 30 min the main training phase.
3. Intensity: Firstly, set at 45% Wmax, and progressively increased 5% per week
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
20 Years
30 Years
MALE
Yes
Sponsors
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Chang Gung Memorial Hospital
OTHER
Responsible Party
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Jong-Shyan Wang
Consultant
Principal Investigators
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Jong-Shyan Wang, PhD
Role: PRINCIPAL_INVESTIGATOR
Chang Gung Memorial Hospital
Locations
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Chang Gung University
Taoyuan District, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Jong-Shyan Wong, PhD
Role: primary
References
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Hoppeler H. Moderate Load Eccentric Exercise; A Distinct Novel Training Modality. Front Physiol. 2016 Nov 16;7:483. doi: 10.3389/fphys.2016.00483. eCollection 2016.
Haynes A, Linden MD, Chasland LC, Nosaka K, Maiorana A, Dawson EA, Dembo LH, Naylor LH, Green DJ. Acute impact of conventional and eccentric cycling on platelet and vascular function in patients with chronic heart failure. J Appl Physiol (1985). 2017 Jun 1;122(6):1418-1424. doi: 10.1152/japplphysiol.01057.2016. Epub 2017 Mar 16.
Lindstedt SL, LaStayo PC, Reich TE. When active muscles lengthen: properties and consequences of eccentric contractions. News Physiol Sci. 2001 Dec;16:256-61. doi: 10.1152/physiologyonline.2001.16.6.256. No abstract available.
LaStayo PC, Ewy GA, Pierotti DD, Johns RK, Lindstedt S. The positive effects of negative work: increased muscle strength and decreased fall risk in a frail elderly population. J Gerontol A Biol Sci Med Sci. 2003 May;58(5):M419-24. doi: 10.1093/gerona/58.5.m419.
Other Identifiers
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201900415A3C
Identifier Type: -
Identifier Source: org_study_id
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