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Eccentric Exercise and Oxidative Stress

NCT ID: NCT01728675

Last Updated: 2012-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-05-31

Study Completion Date

2012-07-31

Brief Summary

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The purpose of the present investigation is to compare the responses and adaptations of young and elderly individuals to repeated eccentric exercise in regards to muscle function and redox homeostasis in a side-by-side comparison.

Detailed Description

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Despite the progress of analytic techniques and the refinement of study designs, striking disagreement exists among studies regarding the influence of exercise on muscle function and redox homeostasis in the elderly. A specific exercise protocol will be applied (the repeated eccentric model) to produce long-lasting and extensive changes in redox biomarkers and to examine more easily the potential effects of aging. Ten young men and ten elderly men will underwent an isokinetic eccentric exercise session, which will be repeated after three weeks. Muscle function indices and redox biomarkers will be assessed in urine, plasma or erythrocytes pre exercise, immediately post exercise, 2 and 4 days post exercise.

Conditions

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Aging Muscle Damage Oxidative Stress

Keywords

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Aging Skeletal muscle Biomarkers Adaptation

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Young group

Participants will underwent two isokinetic eccentric exercise sessions

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

Participants will perform two isokinetic eccentric exercise bouts

Elderly group

Participants will underwent two isokinetic eccentric exercise sessions

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

Participants will perform two isokinetic eccentric exercise bouts

Interventions

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Exercise

Participants will perform two isokinetic eccentric exercise bouts

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* subject provides written informed consent
* physiological health profile
* stable at their anthropometric characteristics for at least the last year

Exclusion Criteria

* muscle disease
* prior history of musculoskeletal injury to the lower limbs
* smokers
* consumed any nutritional supplement the last 3 months
* performed intense eccentric exercise the last 6 months
* non Caucasian
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Aristotle University Of Thessaloniki

OTHER

Sponsor Role collaborator

European University Cyprus

OTHER

Sponsor Role lead

Responsible Party

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Dr. Anastasios Theodorou

Researcher

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Michalis G Nikolaidis, PhD

Role: STUDY_CHAIR

Aristotle University Of Thessaloniki

Locations

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European University Cyprus

Nicosia, , Cyprus

Site Status

Countries

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Cyprus

References

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Nikolaidis MG, Kyparos A, Vrabas IS. F(2)-isoprostane formation, measurement and interpretation: the role of exercise. Prog Lipid Res. 2011 Jan;50(1):89-103. doi: 10.1016/j.plipres.2010.10.002. Epub 2010 Oct 15.

Reference Type BACKGROUND
PMID: 20951733 (View on PubMed)

Nikolaidis MG, Jamurtas AZ. Blood as a reactive species generator and redox status regulator during exercise. Arch Biochem Biophys. 2009 Oct 15;490(2):77-84. doi: 10.1016/j.abb.2009.08.015. Epub 2009 Aug 25.

Reference Type BACKGROUND
PMID: 19712664 (View on PubMed)

Nikolaidis MG, Kyparos A, Spanou C, Paschalis V, Theodorou AA, Vrabas IS. Redox biology of exercise: an integrative and comparative consideration of some overlooked issues. J Exp Biol. 2012 May 15;215(Pt 10):1615-25. doi: 10.1242/jeb.067470.

Reference Type BACKGROUND
PMID: 22539728 (View on PubMed)

Theodorou AA, Nikolaidis MG, Paschalis V, Sakellariou GK, Fatouros IG, Koutedakis Y, Jamurtas AZ. Comparison between glucose-6-phosphate dehydrogenase-deficient and normal individuals after eccentric exercise. Med Sci Sports Exerc. 2010 Jun;42(6):1113-21. doi: 10.1249/MSS.0b013e3181c67ecd.

Reference Type BACKGROUND
PMID: 19997026 (View on PubMed)

Panayiotou G, Paschalis V, Nikolaidis MG, Theodorou AA, Deli CK, Fotopoulou N, Fatouros IG, Koutedakis Y, Sampanis M, Jamurtas AZ. No adverse effects of statins on muscle function and health-related parameters in the elderly: an exercise study. Scand J Med Sci Sports. 2013 Oct;23(5):556-67. doi: 10.1111/j.1600-0838.2011.01437.x. Epub 2012 Jan 31.

Reference Type BACKGROUND
PMID: 22288788 (View on PubMed)

Other Identifiers

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EUC-019

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

EUC-017

Identifier Type: -

Identifier Source: org_study_id