The Effects of Moderate Intensity Cycle Ergometer vs. Treadmill Training on Physiological Resilience in Older Adults
NCT ID: NCT06955676
Last Updated: 2025-05-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
36 participants
INTERVENTIONAL
2024-06-01
2026-02-01
Brief Summary
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Detailed Description
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The scientific data establishing the beneficial effects of exercise is undeniable, and the advantages of exercise considerably outweigh the hazards in most adults. Although the existing evidence supports that exercise interventions are a potent tool to foster resilience in older adults, there is still a need of future studies regarding this information. Aerobic exercise (AE), one of the most recommended exercise types by the literature, has also been stated as a beneficial tool to promote physiological resilience at all stages of life through increased growth factor expression and neuroplasticity, which lower the destructive effects of chronic stress. Also, aerobic fitness has been shown to be one of the best predictors of resilience. Government guidelines recommend performing moderate-intensity AE 150 minutes per week. However, the literature does not elaborate on the details of AE interventions on physiological resilience and there is a lack of information on which AE modality is better for this purpose. Although the literature supports the idea of AE being a beneficial tool to improve health and physical fitness goals as well as resilience, it can clearly be seen that there is a need for future research regarding both the comparison of AE modalities in older adults and the effects of AE intervention to promote physiological resilience. Thus, this study will be the first to compare the effects of moderate intensity time-matched AE modalities (cycle ergometer versus treadmill training versus control group) on the parameters associated with physiological resilience (muscle mass/strength, cognition, dexterity, functional ability, cardiorespiratory fitness, and neuromuscular function) in older adults. The intervention period will last 5 weeks, 3 days a week, with 40-minute sessions. The research question will be 'Which AE modality is better in improving determinants of physiological resilience?'. This work will allow us to understand the relationship between AE and physiological resilience in a more detailed way and to prescribe better exercise prescriptions in the future.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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treadmill exercise
All participants should visit the research unit and attend the sessions 3 times a week for 5 weeks. Participants in this group will conduct moderate-intensity (64-76% of Heart rate maximum) treadmill training for 40 minutes each session. There is a 5-min warm-up before the intervention and a 5-min cool-down period after the intervention.
treadmill exercise
Intervention consists of exercises only. Participants in this group will walk on a treadmill. The heart rates of the participants will be monitored with a heart rate monitor while exercising in order to maintain moderate-intensity.
cycle ergometer exercise
All participants should visit the research unit and attend the sessions 3 times a week for 5 weeks. Participants in this group will conduct moderate-intensity (64-76% of Heart rate maximum) cycle ergometer training for 40 minutes each session. There is a 5-min warm-up before the intervention and a 5-min cool-down period after the intervention.
cycle ergometer exercise
Intervention consists of exercises only. Participants in this group will cycle on an ergometer. The heart rates of the participants will be monitored with a heart rate monitor while exercising in order to maintain moderate-intensity.
control group
The control group will receive 'no intervention'.
No interventions assigned to this group
Interventions
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treadmill exercise
Intervention consists of exercises only. Participants in this group will walk on a treadmill. The heart rates of the participants will be monitored with a heart rate monitor while exercising in order to maintain moderate-intensity.
cycle ergometer exercise
Intervention consists of exercises only. Participants in this group will cycle on an ergometer. The heart rates of the participants will be monitored with a heart rate monitor while exercising in order to maintain moderate-intensity.
Eligibility Criteria
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Inclusion Criteria
* Participants who are able to perform exercises safely and freely
* Participants who are 60-80 years old
Exclusion Criteria
* Severe cognitive impairment
* Joint disorders avoiding exercise participation
* A recent heart attack, unstable angina, or severe heart failure
* Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
* Participants who are currently engaging in more than 150 min of moderate-intensity exercise per week or 75 min of vigorous-intensity exercise per week (WHO physical activity recommendations)
60 Years
80 Years
ALL
Yes
Sponsors
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University of Nottingham
OTHER
Responsible Party
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Bethan Phillips
Professor of Translational Physiology
Principal Investigators
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Mehmet C Yildirim, PhD
Role: STUDY_DIRECTOR
The University of Nottingham
Locations
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The University of Nottingham/Medical School
Derby, Derbyshire, United Kingdom
Countries
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Central Contacts
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Facility Contacts
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References
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Hadley EC, Kuchel GA, Newman AB; Workshop Speakers and Participants. Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging. J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):980-990. doi: 10.1093/gerona/glx015.
Cosco TD, Howse K, Brayne C. Healthy ageing, resilience and wellbeing. Epidemiol Psychiatr Sci. 2017 Dec;26(6):579-583. doi: 10.1017/S2045796017000324. Epub 2017 Jul 6.
Sampedro-Piquero P, Moreno-Fernandez RD. Building Resilience with Aerobic Exercise: Role of FKBP5. Curr Neuropharmacol. 2021;19(8):1156-1160. doi: 10.2174/1570159X19666210408124937.
Arida RM, Teixeira-Machado L. The Contribution of Physical Exercise to Brain Resilience. Front Behav Neurosci. 2021 Jan 20;14:626769. doi: 10.3389/fnbeh.2020.626769. eCollection 2020.
Lee SY, Ahn S, Kim YJ, Ji MJ, Kim KM, Choi SH, Jang HC, Lim S. Comparison between Dual-Energy X-ray Absorptiometry and Bioelectrical Impedance Analyses for Accuracy in Measuring Whole Body Muscle Mass and Appendicular Skeletal Muscle Mass. Nutrients. 2018 Jun 7;10(6):738. doi: 10.3390/nu10060738.
Mijnarends DM, Meijers JM, Halfens RJ, ter Borg S, Luiking YC, Verlaan S, Schoberer D, Cruz Jentoft AJ, van Loon LJ, Schols JM. Validity and reliability of tools to measure muscle mass, strength, and physical performance in community-dwelling older people: a systematic review. J Am Med Dir Assoc. 2013 Mar;14(3):170-8. doi: 10.1016/j.jamda.2012.10.009. Epub 2012 Dec 29.
Scott JM, Martin DS, Ploutz-Snyder R, Matz T, Caine T, Downs M, Hackney K, Buxton R, Ryder JW, Ploutz-Snyder L. Panoramic ultrasound: a novel and valid tool for monitoring change in muscle mass. J Cachexia Sarcopenia Muscle. 2017 Jun;8(3):475-481. doi: 10.1002/jcsm.12172. Epub 2017 Jan 3.
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Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di Iorio A, Corsi AM, Rantanen T, Guralnik JM, Ferrucci L. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol (1985). 2003 Nov;95(5):1851-60. doi: 10.1152/japplphysiol.00246.2003.
Dourado VZ, Nishiaka RK, Simoes MSMP, Lauria VT, Tanni SE, Godoy I, Gagliardi ART, Romiti M, Arantes RL. Classification of cardiorespiratory fitness using the six-minute walk test in adults: Comparison with cardiopulmonary exercise testing. Pulmonology. 2021 Nov-Dec;27(6):500-508. doi: 10.1016/j.pulmoe.2021.03.006. Epub 2021 May 4.
Santana MG, de Lira CA, Passos GS, Santos CA, Silva AH, Yoshida CH, Tufik S, de Mello MT. Is the six-minute walk test appropriate for detecting changes in cardiorespiratory fitness in healthy elderly men? J Sci Med Sport. 2012 May;15(3):259-65. doi: 10.1016/j.jsams.2011.11.249. Epub 2011 Dec 11.
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Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M; European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010 Jul;39(4):412-23. doi: 10.1093/ageing/afq034. Epub 2010 Apr 13.
Gojanovic M, Holloway-Kew KL, Hyde NK, Mohebbi M, Shivappa N, Hebert JR, O'Neil A, Pasco JA. The Dietary Inflammatory Index Is Associated with Low Muscle Mass and Low Muscle Function in Older Australians. Nutrients. 2021 Apr 1;13(4):1166. doi: 10.3390/nu13041166.
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Other Identifiers
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FMHS 367-0923
Identifier Type: -
Identifier Source: org_study_id
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