Role of Aging and Individual Variation in Exercise Training Responsiveness
NCT ID: NCT06471569
Last Updated: 2025-11-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
26 participants
INTERVENTIONAL
2025-04-02
2027-03-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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Low Amount/Moderate Intensity (Low/Mod)
Six months of low amount/moderate intensity aerobic exercise
Low/Mod
Aerobic exercise at 50% peak oxygen consumption for the number of weekly minutes prescribed in the original STRRIDE trial
High Amount/Moderate Intensity (High/Mod)
Six months of high amount/moderate intensity aerobic exercise
High/Mod
Aerobic exercise at 50% peak oxygen consumption for the number of weekly minutes prescribed in the original STRRIDE trial
High Amount/Vigorous Intensity (High/Vig)
Six months of high amount/vigorous intensity aerobic exercise
High/Vig
Aerobic exercise at 75% peak oxygen consumption for the number of weekly minutes prescribed in the original STRRIDE trial
Interventions
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Low/Mod
Aerobic exercise at 50% peak oxygen consumption for the number of weekly minutes prescribed in the original STRRIDE trial
High/Mod
Aerobic exercise at 50% peak oxygen consumption for the number of weekly minutes prescribed in the original STRRIDE trial
High/Vig
Aerobic exercise at 75% peak oxygen consumption for the number of weekly minutes prescribed in the original STRRIDE trial
Eligibility Criteria
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Inclusion Criteria
* Body Mass Index (BMI) \> 18 and \< 45 kg/m2
* Stable dose (≥1 month) of any cardiometabolic medications
Exclusion Criteria
* Current use of tobacco or any nicotine products, including e-cigarettes
* Insulin-dependent diabetes
* Active untreated hypothyroidism with thyroid stimulating hormone (TSH) concentrations \> 10.0 uIU/mL
* Systemic inflammatory or connective tissue disease, chronic infectious disease, chronic pulmonary disease or symptomatic cardiovascular disease with positive functional study by ECG or imaging
* Current, actively treated malignancy other than dermatologic conditions
* Absolute contraindications to exercise testing: ongoing unstable angina; uncontrolled cardiac arrhythmia with hemodynamic compromise; active endocarditis; symptomatic severe aortic stenosis; decompensated heart failure; acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis; acute myocarditis or pericarditis; acute aortic dissection; physical disability that precludes safe and adequate testing
* Relative contraindications to exercise testing: known obstructive left main coronary artery stenosis; moderate to severe aortic stenosis with uncertain relation to symptoms; tachyarrhythmias with uncontrolled ventricular rates; acquired advanced or complete heart block; hypertrophic obstructive cardiomyopathy with severe resting gradient; recent stroke or transient ischemic attack; mental impairment with limited ability to cooperate; uncorrected medical conditions, such as hypertension, significant anemia, important electrolyte imbalance, and hyperthyroidism
* Modified testing contraindications: acute myocardial infarction (MI) within six months; resting hypertension with systolic or diastolic blood pressures \>160/90 mmHg
* Unable to safely participate in an exercise program per study protocol per PI discretion
* Planned, intentional weight loss during study
60 Years
90 Years
ALL
No
Sponsors
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National Institutes of Health (NIH)
NIH
National Institute on Aging (NIA)
NIH
Duke University
OTHER
Responsible Party
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Principal Investigators
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Leanna M Ross, PhD
Role: PRINCIPAL_INVESTIGATOR
Duke University
Locations
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Duke Center for Living
Durham, North Carolina, United States
Countries
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Central Contacts
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Facility Contacts
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Alyssa Sudnick, MS
Role: primary
Other Identifiers
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Pro00115833
Identifier Type: -
Identifier Source: org_study_id