Anaerobic Exercise and Mental Acuity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

23 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-15

Study Completion Date

2023-11-15

Brief Summary

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This is a randomized controlled trial to examine the effect of anaerobic activity (e.g., weight training) on gut microbiome metabolism and neurological health in healthy sedentary men.

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Detailed Description

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The human gut microbiome, which houses over 2,000 distinct bacterial species, has recently been characterized as a highly influential force on the health and longevity of its host. By way of several distinct pathways comprising the "microbiome-gut-brain axis", this diverse population is known to communicate with the human brain in a bidirectional manner and is implicated in the pathophysiology of several metabolic and psychological disease states. The ability to support a healthy, diverse microbiome through modifiable behavioral interventions - such as diet and exercise - is a topic of growing interest. Most of the evidence pertaining to the relationship between physical activity and the gut-brain axis at this time, however, investigates the influence of aerobic exercise providing limited insight to how other modalities of physical activity may differ. Specifically, this study will examine the impact of an 8-week weight training protocol on gut microbiome metabolism and neurological health in healthy sedentary men. Participants will be randomly assigned to the intervention group or the waitlist control group.

Conditions

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Depression LPS Mood

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

randomized controlled trial (waitlist control)

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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weight training

A prescribed 8-week training protocol

Group Type EXPERIMENTAL

weight training

Intervention Type OTHER

weight training

no prescribed weight training

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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weight training

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* free of any existing medical diagnoses
* willing and able to participate in moderate to vigorous exercise as determined by the ACSM Health/Fitness Facility Preparticipation Screening Questionnaire
* sedentary (defined as a score \<14 on the Godin-Shepard Leisure Time Physical Activity Questionnaire (GSLTQ))
* equipped with access to a complete gym

Exclusion Criteria

* antibiotic use within the past six months
* prebiotic, probiotic, or high-dose antioxidant supplementation within the past 6 months
* smoker (cigarettes and/or marijuana)
* regular laxative use
* blood pressure \>129/80 at baseline

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes