Exploring the Effects of Exercise Combined With BFRT on Healthy and Patients With CKD
NCT ID: NCT07288905
Last Updated: 2025-12-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
120 participants
INTERVENTIONAL
2025-10-04
2030-12-31
Brief Summary
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Detailed Description
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To address this vicious cycle, aerobic and resistance training have been shown to mitigate these effects. Previous studies have reported that such exercise interventions can reduce fatigue and improve VO₂ peak in individuals with CKD. However, these exercise programs often involve high loads and frequencies, which may not be feasible for some CKD patients, particularly those with comorbidities such as diabetes or cardiovascular disease.
The effectiveness of blood flow restriction (BFR) exercise compared with high-load training has been demonstrated in older adults, showing improvements in functional ability and muscular adaptation. Therefore, the purpose of this study is to investigate the effects of incorporating blood flow restriction during exercise on cardiopulmonary function and exercise capacity in patients with CKD.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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healthy
We will provide BFR combined with exercise
Blood flow restriction
Blood flow restriction intervention will combined aerobic exercise and resistance exercise. The program will be conducted 2 times per week over a 12 weeks
Resistance exercise
The resistance exercise will bilateral leg extension. The program will be conducted 2 times per week over a 12 weeks
Disease and exercise suggestion
The participants will received self-care technique and home-based exercise approach
Aerobic exercise
The aerobic exercise intervention will utilize stationary bike. The program will be conducted 2 times per week over a 12 weeks
CKD usual care group
We will provide patient education, home-based moderate to low-intensity rehabilitation
Disease and exercise suggestion
The participants will received self-care technique and home-based exercise approach
CKD traditional rehabilitation group
We will provide aerobic exercise, resistance exercise training, and patient education
Resistance exercise
The resistance exercise will bilateral leg extension. The program will be conducted 2 times per week over a 12 weeks
Disease and exercise suggestion
The participants will received self-care technique and home-based exercise approach
Aerobic exercise
The aerobic exercise intervention will utilize stationary bike. The program will be conducted 2 times per week over a 12 weeks
CKD BFR group
We will provide BFR combined with exercise and patient education
Blood flow restriction
Blood flow restriction intervention will combined aerobic exercise and resistance exercise. The program will be conducted 2 times per week over a 12 weeks
Resistance exercise
The resistance exercise will bilateral leg extension. The program will be conducted 2 times per week over a 12 weeks
Aerobic exercise
The aerobic exercise intervention will utilize stationary bike. The program will be conducted 2 times per week over a 12 weeks
Interventions
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Blood flow restriction
Blood flow restriction intervention will combined aerobic exercise and resistance exercise. The program will be conducted 2 times per week over a 12 weeks
Resistance exercise
The resistance exercise will bilateral leg extension. The program will be conducted 2 times per week over a 12 weeks
Disease and exercise suggestion
The participants will received self-care technique and home-based exercise approach
Aerobic exercise
The aerobic exercise intervention will utilize stationary bike. The program will be conducted 2 times per week over a 12 weeks
Eligibility Criteria
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Inclusion Criteria
* Aged 20\~85 years old
* eGFR\< 90 ml/min/1.73 m2 over 3 months
* Stable condition without worsening in the past 3 months
* Ability to understand and follow verbal commends and cooperate with an exercise training program
Exclusion Criteria
* Severe pulmonary or cardiovascular diseases (e.g., pulmonary hypertension, chronic obstructive pulmonary disease (COPD), heart failure, cardiac arrhythmia)
* Presence of a cardiac pacemaker or a history of myocardial infarction within the past six months
* Severe musculoskeletal or neuromuscular disorders (e.g., advanced arthritis, limb amputation, post-polio syndrome, Parkinson's disease)
* Unstable vital signs (e.g., systolic blood pressure ≥180 mmHg, diastolic blood pressure ≥90 mmHg, requiring vasopressors, or resting heart rate \>100 bpm)
* Prone to bruising
* Recent inflection \< 1 month
* Pregnancy
* Kidney function impairment
* Cancer
* Simultaneously participating in other research
CKD
* Severe uncontrolled metabolic diseases (e.g., hyperthyroidism, diabetes, hypertension, hyperlipidemia, etc.)
* Severe pulmonary or cardiovascular diseases (e.g., pulmonary hypertension, chronic obstructive pulmonary disease (COPD), heart failure, cardiac arrhythmia)
* Presence of a cardiac pacemaker or a history of myocardial infarction within the past six months
* Severe musculoskeletal or neuromuscular disorders (e.g., advanced arthritis, limb amputation, post-polio syndrome, Parkinson's disease)
* Unstable vital signs (e.g., systolic blood pressure ≥180 mmHg, diastolic blood pressure ≥90 mmHg, requiring vasopressors, or resting heart rate \>100 bpm)
* Abnormal blood biochemical parameters (e.g., white blood cell count \<2500/mm³, hemoglobin \<8 mg/dL, total bilirubin \>3 mg/dL, liver enzymes (GOT/AST, GPT/ALT) \>3 times the upper limit of normal, platelet count \<75,000/mm³
* Sensory or motor dysfunctions that affect walking ability
* Diagnosed systemic diseases under ongoing treatment (e.g., systemic lupus erythematosus, cancer, malignancies).
20 Years
85 Years
ALL
Yes
Sponsors
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National Cheng Kung University
OTHER
Responsible Party
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Kun-Ling Tsai
Professor and Chair, Department of Physical Therapy
Principal Investigators
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Kun-Ling Tasi, PhD
Role: PRINCIPAL_INVESTIGATOR
Department of Physical Therapy, National Cheng Kung University
Locations
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National Cheng Kung University Hospital
Tainan, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Kun-Ling Tasi, PhD
Role: primary
Other Identifiers
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B-ER-113-450
Identifier Type: -
Identifier Source: org_study_id