Somesthesic Role of the Ventro-lateral Prefrontal Cortex in Speech Motor Learning

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-20

Study Completion Date

2021-07-06

Brief Summary

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These studies test the hypothesis that frontal areas of the brain participate in the cortical networks involved in the somotosensory processing that happens during speech motor learning.

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Detailed Description

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This work aims to study the role of sensory systems in human motor learning and specifically addresses the involvement of somatosensory cortical networks in motor learning of speech. Previous studies in the literature have highlighted the plasticity of cortical sensory networks, notably the primary and secondary somatosensory cortex and the ventral premotor cortex, during motor learning tasks. The present project focuses on the somatosensory region with connections to the sensorimotor regions of the frontal and parietal cortex. We propose to use neuroimaging (fMRI), in order to verify which areas in the prefrontal cortex are part of the sensorimotor network used in the learning of speech motor tasks in humans. Subjects will be tested in the fMRI scanner while performing either a behavioral task in which the auditory feedback of their own speech is altered or while performing a vibrotactile discrimination task.

Conditions

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Speech Motor Activity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Adaptation to altered auditory feedback

fMRI measurement of brain activity during speech production under altered auditory feedback

Group Type EXPERIMENTAL

Speech adaptation

Intervention Type BEHAVIORAL

Sensorimotor adaptation in speech

fMRI

Intervention Type OTHER

fMRI measurement of brain activity

Speech production

fMRI measurement of brain activity during normal speech production

Group Type EXPERIMENTAL

fMRI

Intervention Type OTHER

fMRI measurement of brain activity

Speech production

Intervention Type BEHAVIORAL

Speech production task

Vibrotactile discrimination

fMRI measurement of brain activity during a vibrotactile discrimination task

Group Type EXPERIMENTAL

Vibrotactile Discrimination

Intervention Type BEHAVIORAL

Vibrotactile Discrimination

fMRI

Intervention Type OTHER

fMRI measurement of brain activity

Interventions

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Speech adaptation

Sensorimotor adaptation in speech

Intervention Type BEHAVIORAL

Vibrotactile Discrimination

Intervention Type BEHAVIORAL

fMRI

fMRI measurement of brain activity

Intervention Type OTHER

Speech production

Speech production task

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Right-handed subjects
* Subjects fluent in French
* Signed informed consent
* Affiliation to or beneficiary of a Social Security scheme

Exclusion Criteria

* Left-handed subjects
* Criteria for contraindications to protocol fMRI scans
* Existence of a severe general condition: cardiac, respiratory, hematological, renal, hepatic, cancerous.
* Hearing, language (including dyslexia), neurological or psychiatric disorders.
* Participation in other ongoing intervention research protocols with exclusionary period or within the previous week
* Drug treatment likely to modulate brain activity: benzodiazepines, antidepressants, neuroleptics, lithium, etc.
* Protected persons referred to in articles L1121 5 to L1121 8 of the French CSP:

* Pregnant women, parturients, nursing mothers,
* Persons deprived of liberty by a judicial or administrative decision,
* Persons under psychiatric care,
* Individuals admitted to a health or social institution for purposes other than research,
* Minors,
* Persons over the age of majority who are subject to a legal protection measure or who are unable to express their consent

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes