Sensory Memory in Speech Motor Learning

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-01

Study Completion Date

2025-07-31

Brief Summary

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The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its involvement in learning.

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Detailed Description

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This study will assess the relationship between sensory working memory and speech motor adaptation using a between subjects design. Participants will be assigned to one of two groups. Each group will undergo both auditory and somatosensory working memory tests. This will be followed by adaptation to altered auditory feedback. Using a different group of subjects, cTBS will be used to disrupt neural activity in Brodmann area 46v in ventrolateral prefrontal cortex to test its involvement in adaptation. One set of tests will focus on the effects of cTBS on both auditory and somatosensory working memory. A second set of tests will focus on the effects of cTBS on speech motor adaptation to altered auditory feedback. Both working memory and adaptation are assessed on 0 to 100 scales.

Conditions

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Speech Consolidation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Adaptation to Altered Auditory Feedback

Group Type EXPERIMENTAL

Adaptation

Intervention Type BEHAVIORAL

Sensorimotor adaptation in speech

Auditory Sensory Memory

Group Type EXPERIMENTAL

Adaptation

Intervention Type BEHAVIORAL

Sensorimotor adaptation in speech

Somatosensory Sensory Memory

Group Type EXPERIMENTAL

Adaptation

Intervention Type BEHAVIORAL

Sensorimotor adaptation in speech

Adaptation to Altered Auditory Feedback + cTBS to 46v

Group Type EXPERIMENTAL

Adaptation

Intervention Type BEHAVIORAL

Sensorimotor adaptation in speech

cTBS

Intervention Type OTHER

continuous theta-burst stimulation

Sensory Memory + cTBS to 46v

Group Type EXPERIMENTAL

Adaptation

Intervention Type BEHAVIORAL

Sensorimotor adaptation in speech

cTBS

Intervention Type OTHER

continuous theta-burst stimulation

Interventions

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Adaptation

Sensorimotor adaptation in speech

Intervention Type BEHAVIORAL

cTBS

continuous theta-burst stimulation

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* right handed adults
* no known physical or neurological abnormalities

Exclusion Criteria

* patients with:
* cardiac pacemaker
* surgical clips or values on the heart
* implants
* metal or metallic fragments in any part of the body
* pregnancy
* claustrophobia
* a personal or family history of epilepsy
* currently taking antipsychotic drugs
* currently taking antidepressant drugs
* currently taking antianxiety drugs
* history of concussion.

Minimum Eligible Age

21 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes