TMS-based Assessment of Mental Training Effects on Motor Learning in Healthy Participants
NCT ID: NCT04784832
Last Updated: 2025-01-03
Study Results
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Basic Information
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RECRUITING
NA
556 participants
INTERVENTIONAL
2024-04-08
2027-04-07
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
FACTORIAL
BASIC_SCIENCE
NONE
Study Groups
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Sequence 1 - Training with same task - Long follow-up
Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Mental training
Training to perform the task by imaging doing the task
Sequence 1 - Training with same task - Short follow-up
Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Mental training
Training to perform the task by imaging doing the task
Sequence 1 - Training with different tasks - Long follow-up
Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Mental training
Training to perform the task by imaging doing the task
Sequence 1 - Training with different tasks - Short follow-up
Motor task (different task in immediate post test) Transcranial magnetic stimulation Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Mental training
Training to perform the task by imaging doing the task
Sequence 1 - Training with muscle contractions - Long follow-up
Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Mental training
Training to perform the task by imaging doing the task
Sequence 1 - Training with muscle contractions - Short follow-up
Motor task (isometric muscle contractions in immediate post test) Transcranial magnetic stimulation Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Mental training
Training to perform the task by imaging doing the task
Sequence 1 - Control
Motor task (Pretest and Posttests on the same task) Transcranial magnetic stimulation No mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Sequence 2 - Physical training with perturbation during preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Robotic arm
External perturbation of force field induced by robotic arm
Physical training
Training to perform the task by actually doing the task
Sequence 2 - Physical training with perturbation during preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Robotic arm
External perturbation of force field induced by robotic arm
Physical training
Training to perform the task by actually doing the task
Sequence 2 - Physical training with perturbation after preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Robotic arm
External perturbation of force field induced by robotic arm
Physical training
Training to perform the task by actually doing the task
Sequence 2 - Physical training with perturbation after preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Physical training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Robotic arm
External perturbation of force field induced by robotic arm
Physical training
Training to perform the task by actually doing the task
Sequence 2 - Mental training with perturbation during preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Robotic arm
External perturbation of force field induced by robotic arm
Mental training
Training to perform the task by imaging doing the task
Sequence 2 - Mental training with perturbation during preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Robotic arm
External perturbation of force field induced by robotic arm
Mental training
Training to perform the task by imaging doing the task
Sequence 2 - Mental training with perturbation after preparation - Long follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Robotic arm
External perturbation of force field induced by robotic arm
Mental training
Training to perform the task by imaging doing the task
Sequence 2 - Mental training with perturbation after preparation - Short follow-up
Motor task (Pretest and Posttests) Transcranial magnetic stimulation External pertubation (robotic arm) Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Robotic arm
External perturbation of force field induced by robotic arm
Mental training
Training to perform the task by imaging doing the task
Sequence 3 - Training (same task) - Long follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Peripheral Nerve Stimulation
Electric stimulation of the nerves
Paired Associative Stimulation
Combined magnetic and electric stimulation of cortex and nerve, respectively
Cervicomedullar stimulation
Electric stimulation of the muscle
Mental training
Training to perform the task by imaging doing the task
Sequence 3 - Training (same task) - Short follow-up
Paired Associative Stimulation Mental training (same as the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Peripheral Nerve Stimulation
Electric stimulation of the nerves
Paired Associative Stimulation
Combined magnetic and electric stimulation of cortex and nerve, respectively
Cervicomedullar stimulation
Electric stimulation of the muscle
Mental training
Training to perform the task by imaging doing the task
Sequence 3 - Training (different task) - Long follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Peripheral Nerve Stimulation
Electric stimulation of the nerves
Paired Associative Stimulation
Combined magnetic and electric stimulation of cortex and nerve, respectively
Cervicomedullar stimulation
Electric stimulation of the muscle
Mental training
Training to perform the task by imaging doing the task
Sequence 3 - Training (different task) - Short follow-up
Paired Associative Stimulation Mental training (different of the motor task) Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Peripheral Nerve Stimulation
Electric stimulation of the nerves
Paired Associative Stimulation
Combined magnetic and electric stimulation of cortex and nerve, respectively
Cervicomedullar stimulation
Electric stimulation of the muscle
Mental training
Training to perform the task by imaging doing the task
Sequence 3 - Control 1
Mental Training Motor task (same as the motor task) Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Peripheral Nerve Stimulation
Electric stimulation of the nerves
Cervicomedullar stimulation
Electric stimulation of the muscle
Mental training
Training to perform the task by imaging doing the task
Sequence 3 - Control 2
Paired Associative Stimulation Motor task Transcranial magnetic stimulation Peripheral nerve stimulation Cervicomedullar stimulation
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Peripheral Nerve Stimulation
Electric stimulation of the nerves
Paired Associative Stimulation
Combined magnetic and electric stimulation of cortex and nerve, respectively
Cervicomedullar stimulation
Electric stimulation of the muscle
Sequence 4 - Immobilization - Short follow-up
Transcranial magnetic stimulation Arm immobilization Motor task Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Wrist
Short-term immobilization of the arm
Mental training
Training to perform the task by imaging doing the task
Sequence 4 - Immobilization - Long follow-up
Transcranial magnetic stimulation Arm immobilization Motor task Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Wrist
Short-term immobilization of the arm
Mental training
Training to perform the task by imaging doing the task
Sequence 4 - Cathodal - Short follow-up
Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Transcranial direct current stimulation
Electric stimulation of the cortex
Mental training
Training to perform the task by imaging doing the task
Sequence 4 - Cathodal - Long follow-up
Transcranial magnetic stimulation Cathodal transcranial direct current stimulation Motor task Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Transcranial direct current stimulation
Electric stimulation of the cortex
Mental training
Training to perform the task by imaging doing the task
Sequence 4 - Anodal - Short follow-up
Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Transcranial direct current stimulation
Electric stimulation of the cortex
Mental training
Training to perform the task by imaging doing the task
Sequence 4 - Anodal - Long follow-up
Transcranial magnetic stimulation Anodal transcranial direct current stimulation Motor task Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Transcranial direct current stimulation
Electric stimulation of the cortex
Mental training
Training to perform the task by imaging doing the task
Sequence 4 - Control
Transcranial magnetic stimulation Motor task Mental training
Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Mental training
Training to perform the task by imaging doing the task
Interventions
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Transcranial magnetic stimulation
Magnetic stimulation of the cortex
Peripheral Nerve Stimulation
Electric stimulation of the nerves
Transcranial direct current stimulation
Electric stimulation of the cortex
Paired Associative Stimulation
Combined magnetic and electric stimulation of cortex and nerve, respectively
Wrist
Short-term immobilization of the arm
Robotic arm
External perturbation of force field induced by robotic arm
Cervicomedullar stimulation
Electric stimulation of the muscle
Physical training
Training to perform the task by actually doing the task
Mental training
Training to perform the task by imaging doing the task
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Having given written informed consent
* Affiliated to a social security scheme
Exclusion Criteria
* Person under guardianship, curatorship, safeguard of justice
* Neurological problem that could bias the results of the study (declarative)
* Personal or family history of epilepsy
* Person deprived of liberty by judicial or administrative decision
* Person hospitalized without consent and not subject to legal protection, and person admitted to a health or social institution for purposes other than that of the research
* Person subject to an exclusion period for another research
* Pregnant women or women of childbearing age not using known contraception
* Breastfeeding women
* Person on medication that could influence neurophysiological measures (neuroleptics, anxiolytics, antidepressants)
* Person carrying :
* pacemaker or other device that could interfere with the magnetic field
* Implants (mechanical or electronic: cochlear implants, neural or cardiac pacemakers, infusion pumps, magnetic aneurysm clips, etc.)
* Metallic foreign bodies in the eye or nervous system
* Metallic objects (tattoos, piercings, etc.)
18 Years
60 Years
ALL
Yes
Sponsors
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Institut National de la Santé Et de la Recherche Médicale, France
OTHER_GOV
Responsible Party
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Principal Investigators
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Florent Lebon, PhD
Role: PRINCIPAL_INVESTIGATOR
Institut National de la Santé Et de la Recherche Médicale, France
Locations
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INSERM - U1093 Cognition, Action, and Sensorimotor Plasticity
Dijon, , France
Countries
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Central Contacts
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Facility Contacts
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References
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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2020-A00305-34 / 1
Identifier Type: REGISTRY
Identifier Source: secondary_id
C19-19
Identifier Type: -
Identifier Source: org_study_id
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