Organization and Development of Motor Cortical Circuits for Speech Production in Stuttering

NCT ID: NCT07180628

Last Updated: 2026-02-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-03-31

Study Completion Date

2029-03-31

Brief Summary

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The overall objective of this study is to examine inter effector areas (IEAs) activity and functional connectivity during continuous speech production in stuttering adults.

Detailed Description

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Conditions

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Stutter Stuttering, Adult Stuttering Stuttering, Developmental

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

There will be 50 adults that stutter that participate in this study with a goal of 33 evaluable.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Stutter group

Participants that stutter

Group Type EXPERIMENTAL

Speech Production During functional magnetic resonance imaging (MRI)

Intervention Type BEHAVIORAL

Participants will complete a speech production task with 2 conditions (stuttered, non-stuttered) while undergoing functional MRI to assess brain activity. Brain activity will be compared within subjects for the 2 conditions. The intervention is the combination of tasks delivered to all participants. The speaking task is the intervention (modifying agent) and the MRI is a measurement tool, not a therapeutic or modifying agent.

Interventions

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Speech Production During functional magnetic resonance imaging (MRI)

Participants will complete a speech production task with 2 conditions (stuttered, non-stuttered) while undergoing functional MRI to assess brain activity. Brain activity will be compared within subjects for the 2 conditions. The intervention is the combination of tasks delivered to all participants. The speaking task is the intervention (modifying agent) and the MRI is a measurement tool, not a therapeutic or modifying agent.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Are between the ages of 18-65 years
* Have otherwise normal speech, language, hearing and cognition
* Speak English as their primary language
* Currently stutter

Exclusion Criteria

* Have serious medical or neurological conditions (e.g., stroke, traumatic brain injury, Parkinson's disease, etc.)
* Have had a closed head injury (e.g., concussion)
* Have a reading disorder (e.g., dyslexia)
* Have hearing loss
* Have metal or electronic implants (e.g., cochlear implants, pacemakers, etc.)
* Are currently pregnant
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute on Deafness and Other Communication Disorders (NIDCD)

NIH

Sponsor Role collaborator

University of Michigan

OTHER

Sponsor Role lead

Responsible Party

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Soo-Eun Chang

Associate Professor of Psychiatry

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Soo-Eun Shang, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Locations

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University of Michigan

Ann Arbor, Michigan, United States

Site Status

Countries

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United States

Central Contacts

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Emily Garnett, PhD

Role: CONTACT

734-232-3371

Facility Contacts

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Emily Garnett, PhD

Role: primary

734-232-3371

Other Identifiers

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1R01DC022763-01

Identifier Type: NIH

Identifier Source: secondary_id

View Link

HUM00269390

Identifier Type: -

Identifier Source: org_study_id

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