Activity of the Auditory Cortex During Speech Perception and Speech Production in Stuttering
NCT ID: NCT00148161
Last Updated: 2007-04-27
Study Results
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Basic Information
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UNKNOWN
20 participants
OBSERVATIONAL
2004-11-30
Brief Summary
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Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain.
Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system.
The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.
Detailed Description
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Conditions
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Keywords
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Study Design
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DEFINED_POPULATION
OTHER
Eligibility Criteria
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Inclusion Criteria
* Fluently speaking subjects (for the control group)
* Right handed
* Normal hearing
Exclusion Criteria
* Psychiatric diseases
* Medication with neurological effective drugs
* Implants with magnetic impact
18 Years
MALE
Yes
Sponsors
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University Hospital Muenster
OTHER
Principal Investigators
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Antoinette G Dinnesen, Prof. Dr.
Role: STUDY_DIRECTOR
Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
Arne Knief, Dr.
Role: PRINCIPAL_INVESTIGATOR
Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
Locations
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Institute for Biomagnetism and Biosignalanalysis
Münster, , Germany
Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
Münster, , Germany
Countries
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Central Contacts
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Facility Contacts
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Christo Pantev, Prof. Dr.
Role: primary
Antoinette G Dinnesen, Prof. Dr.
Role: primary
Related Links
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Homepage of the Institute for Biomagnetism and Biosignalanalysis
Other Identifiers
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phonpaed001
Identifier Type: -
Identifier Source: org_study_id