Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
NCT ID: NCT06458153
Last Updated: 2025-06-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
100 participants
INTERVENTIONAL
2025-05-27
2028-07-31
Brief Summary
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1. What regions of the brain's sensory systems show changes in their activity related to speech?
2. To what extent do these regions help listeners detect and correct speech errors?
3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities?
Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).
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Detailed Description
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Participants will be asked to complete up to 6 sessions. Passing a hearing assessment using standard audiological procedures, conducted at the start of the first session, is a requirement for participation. The experimental sessions involve behavior and non-invasive brain imaging.
Investigators will ask participants to perform several short tasks to measure different aspects of their speech production and speech perception (e.g., reading passages or words aloud, making judgements about sounds).
In one session, Investigators will measure electroencephalography (EEG) while participants complete tasks involving producing and hearing speech sounds. Participants will be fitted with an elastic cap and up to 32 non-invasive recording electrodes.
In other sessions, investigators will measure structural and functional magnetic resonance imaging (fMRI). Structural images demonstrate the unique brain anatomy of the participant. Functional images will be obtained while the participant completes specific tasks involving listening, speaking, or completing other motor actions (e.g., pressing a button). All participants will be screened for MRI risk factors prior to each session.
Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Speech behavior and functional imaging
Assessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions.
Neural responses to speech functional localizer
Measuring speech-related brain activity using fMRI during a speech listening task.
Neural responses to silent articulation
Measuring speech-related brain activity using fMRI during a silent articulation task.
Neural responses to self vs. externally generated speech
Measuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech.
Event-related potentials for speech
Measuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech
Neural responses to induced speech errors
Measuring speech-related brain activity using fMRI during conditions that induce auditory speech errors.
Neural responses to sensory-motor adaptation
Measuring brain activity using fMRI during a learning task with sustained altered auditory feedback.
Speech production behaviors
Behavioral measurements of speech during reading passages and words
Auditory acuity testing
Measurements of auditory acuity during listening tasks.
Neural responses to learning a non-speech auditory motor behavior
Mapping of brain areas using fMRI during learning of non-speech sound-evoking movements.
Interventions
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Neural responses to speech functional localizer
Measuring speech-related brain activity using fMRI during a speech listening task.
Neural responses to silent articulation
Measuring speech-related brain activity using fMRI during a silent articulation task.
Neural responses to self vs. externally generated speech
Measuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech.
Event-related potentials for speech
Measuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech
Neural responses to induced speech errors
Measuring speech-related brain activity using fMRI during conditions that induce auditory speech errors.
Neural responses to sensory-motor adaptation
Measuring brain activity using fMRI during a learning task with sustained altered auditory feedback.
Speech production behaviors
Behavioral measurements of speech during reading passages and words
Auditory acuity testing
Measurements of auditory acuity during listening tasks.
Neural responses to learning a non-speech auditory motor behavior
Mapping of brain areas using fMRI during learning of non-speech sound-evoking movements.
Eligibility Criteria
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Inclusion Criteria
* Age 18-49
* Right-handed
* Native English speaker
Cohort 2 (people with cerebellar lesions):
* Age 18 or older
* Right-handed
* Native English speaker
* History of cerebellar stroke
Cohort 3 (controls matched to Cohort 2)
* Age 18 or older
* Right-handed
* Native English speaker
Exclusion Criteria
* Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
* History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
* Hearing loss, defined by pure tone thresholds \>25 decibels (dB) hearing level (HL) at octave frequencies between 250-8000 Hz
* Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
* Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
* Presence of a severe and unmanaged, clinically diagnosed attention disorder
* Clinically diagnosed with or treated for a speech, language, or hearing disorder
* Head circumference greater than 60cm or weight greater than 300 pounds
* History of severe claustrophobia
* Currently pregnant
Cohort 2 (people with cerebellar lesions):
* Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
* History of neurological / neurodegenerative disease or severe brain injury other than stroke
* Hearing loss, defined by pure tone thresholds \>50 dB HL at octave frequencies between 250-4000 Hz
* Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
* Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
* Presence of a severe and unmanaged, clinically diagnosed attention disorder
* Head circumference greater than 60cm or weight greater than 300 pounds
* History of severe claustrophobia
* Currently pregnant
Cohort 3 (controls matched to Cohort 2):
* Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
* History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
* Hearing loss, defined by pure tone thresholds \>50 dB HL at octave frequencies between 250-4000 Hz
* Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
* Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
* Presence of a severe and unmanaged, clinically diagnosed attention disorder
* Clinically diagnosed with or treated for a speech, language, or hearing disorder
* Head circumference greater than 60cm or weight greater than 300 pounds
* History of severe claustrophobia
* Currently pregnant
18 Years
ALL
Yes
Sponsors
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Northwestern University
OTHER
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
University of Pittsburgh
OTHER
Responsible Party
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Jason Bohland
Assistant Professor
Principal Investigators
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Jason W Bohland, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of Pittsburgh
Locations
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University of Pittsburgh
Pittsburgh, Pennsylvania, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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STUDY23070083
Identifier Type: -
Identifier Source: org_study_id
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