Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2021-09-01
2023-07-31
Brief Summary
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Detailed Description
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For these purposes, the investigators will assess in detail the sensitivity, specificity, positive predictive value, and negative predictive value and accuracy of all diagnostic tests. Furthermore, the investigators will calculate the area under the receiver operating characteristic (ROC) curves to verify the optimal diagnostic threshold as reflected by the associated criterion (Ass. Crit.) and Youden Index (YI). To assess possible clinical-instrumental correlations, the investigators will also use a modified algorithm of SVM analysis to calculate a continuous numerical value (the likelihood ratio \[LR\]) providing a measure of voice impairment severity for each participant.
Voice recordings will be performed by asking participants to produce a specific speech task with their usual voice intensity, pitch, and quality. The speech task will consist of a sustained emission of a close mid-front unrounded vowel /e/ for at least 5 seconds. Voice recordings will be collected by using a high-definition audio-recorder placed at a distance of 5 cm from the mouth. Voice samples will be recorded in linear PCM format (.wav) at a sampling rate of 44.1 kHz, with 24-bit sample size. Voice analysis will consist of three separate processes: feature extraction, selection and classification. For feature extraction, the investigators will use the OpenSMILE (audEERING GmbH, Germany), dedicated software. Then, the investigators will select and classify voice feature by using SVM algorithm included in Weka.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients
Patients affected by neurologic disorders showing a prominent voice impairment.
Speech task
Speech task which consists of a sustained emission of the vowel /e/.
Interventions
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Speech task
Speech task which consists of a sustained emission of the vowel /e/.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* bilateral/unilateral hearing loss
* respiratory disorders
* conditions affecting the vocal cords, including nodules.
ALL
Yes
Sponsors
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Neuromed IRCCS
OTHER
Responsible Party
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Antonio Suppa
Principal Investigator
Locations
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Antonio Suppa
Pozzilli, , Italy
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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DIPNEUROSCI_01
Identifier Type: -
Identifier Source: org_study_id
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