Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
126 participants
INTERVENTIONAL
2022-07-01
2025-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Experiment 1
The aim of Experiment 1 is to understand how tACS operates on the neural level
transcranial alternating current stimulation (tACS)
transcranial alternating current stimulation (tACS) used to manipulate how neural activity aligns to speech rhythm, leading to changes in speech perception
electroencephalography (EEG)
analyse rhythmic electroencephalography responses that outlast the stimulation
Experiment 2
The aim of Experiment 2 is to increase efficacy of tACS and, consequently, its potential to play an important role in research and everyday life applications
transcranial alternating current stimulation (tACS)
transcranial alternating current stimulation (tACS) used to manipulate how neural activity aligns to speech rhythm, leading to changes in speech perception
brain imaging (fMRI)
Using brain imaging (fMRI) to predict optimal stimulation protocols for individual participants
Experiment 3
The aim of Experiment 3 is to reveal how tACS can boost speech perception in a multi-speaker scenario.
transcranial alternating current stimulation (tACS)
transcranial alternating current stimulation (tACS) used to manipulate how neural activity aligns to speech rhythm, leading to changes in speech perception
Experiment 4
The aim of Experiment 4 is to combine established techniques to create novel opportunities to improve speech perception
transcranial alternating current stimulation (tACS)
transcranial alternating current stimulation (tACS) used to manipulate how neural activity aligns to speech rhythm, leading to changes in speech perception
electroencephalography (EEG) with neurofeedback
Using neurofeedback to teach participants to enhance their own neural entrainment
Interventions
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transcranial alternating current stimulation (tACS)
transcranial alternating current stimulation (tACS) used to manipulate how neural activity aligns to speech rhythm, leading to changes in speech perception
electroencephalography (EEG)
analyse rhythmic electroencephalography responses that outlast the stimulation
brain imaging (fMRI)
Using brain imaging (fMRI) to predict optimal stimulation protocols for individual participants
electroencephalography (EEG) with neurofeedback
Using neurofeedback to teach participants to enhance their own neural entrainment
Eligibility Criteria
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Inclusion Criteria
* informed written consent
* Absence of pro-epileptogenic drugs
* Absence of visual or hearing impairment incompatible with participation in the study
Exclusion Criteria
* Persons protected by law adults under guardianship or curatorship
* Persons not affiliated to a Social Security scheme
* Subjects with progressive psychiatric or neurological pathology
* Subjects with a contraindication to tCS or MRI (history of epilepsy, severe head injury or brain/spinal cord surgery, cardiac pacemaker/defibrillator, implanted equipment activated by electrical, magnetic or mechanical system, hemostatic clip carriers of intracerebral aneurysms or carotid arteries, orthopedic implant carriers, claustrophobic, pregnancy).
18 Years
50 Years
ALL
Yes
Sponsors
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Centre National de la Recherche Scientifique, France
OTHER
University Hospital, Toulouse
OTHER
Responsible Party
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Principal Investigators
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Mathieu MARX, PU-PH
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Toulouse
Locations
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CHU Toulouse
Toulouse, , France
Countries
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Central Contacts
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Benedikt ZOEFEL, MD
Role: CONTACT
Facility Contacts
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References
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van Bree S, Sohoglu E, Davis MH, Zoefel B. Sustained neural rhythms reveal endogenous oscillations supporting speech perception. PLoS Biol. 2021 Feb 26;19(2):e3001142. doi: 10.1371/journal.pbio.3001142. eCollection 2021 Feb.
Zoefel B, Davis MH, Valente G, Riecke L. How to test for phasic modulation of neural and behavioural responses. Neuroimage. 2019 Nov 15;202:116175. doi: 10.1016/j.neuroimage.2019.116175. Epub 2019 Sep 6.
Zoefel B, Allard I, Anil M, Davis MH. Perception of Rhythmic Speech Is Modulated by Focal Bilateral Transcranial Alternating Current Stimulation. J Cogn Neurosci. 2020 Feb;32(2):226-240. doi: 10.1162/jocn_a_01490. Epub 2019 Oct 29.
Other Identifiers
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2020-A02707-32
Identifier Type: OTHER
Identifier Source: secondary_id
STIMPAROLE
Identifier Type: OTHER
Identifier Source: secondary_id
RC31/20/0340
Identifier Type: -
Identifier Source: org_study_id
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