Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Networks
NCT ID: NCT06608680
Last Updated: 2024-09-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
50 participants
INTERVENTIONAL
2023-05-01
2028-12-31
Brief Summary
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1. At what point after stimulation are the greatest effects on behavior seen
2. How excitatory and inhibitory stimulation affect behavior
Researchers will compare stimulation types against a sham condition to see effects on reading and language behavior.
Participants will be asked to
* undergo reading, language, and cognitive testing
* receive an MRI
* receive TMS stimulation
* perform language, reading, and motor tasks
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
FACTORIAL
BASIC_SCIENCE
DOUBLE
Study Groups
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iTBS/Sham
Adults age 18-30 with typical reading and language abilities
iTBS
Excitatory stimulation of supramarginal gyrus
Sham Stimulation
Sham stimulation of supramarginal gyrus
cTBS/Sham
Adults age 18-30 with typical reading and language abilities
cTBS
Inhibitory stimulation to supramarginal gyrus
Sham Stimulation
Sham stimulation of supramarginal gyrus
Interventions
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iTBS
Excitatory stimulation of supramarginal gyrus
cTBS
Inhibitory stimulation to supramarginal gyrus
Sham Stimulation
Sham stimulation of supramarginal gyrus
Eligibility Criteria
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Inclusion Criteria
* Within a normal range of reading skills as \>85 on the Test of Word Reading Efficiency - Second Edition (TOWRE-2; Torgesen et al., 2012) and the Woodcock-Johnson IV Tests of Achievement (WJ-IV; Schrank et al., 2014)
* Individuals with a documented history of learning disability will not be included. This will be determined via demographics questionnaire.
* Subjects must be between the ages of 18 and 30 to be included. This will be determined via demographics questionnaire.
* Because reading is critically linked to language, only individuals who are native speakers of English will be included in the study. This will be determined via demographics questionnaire.
* The reading network is typically localized to the left side of the brain. However, left-handed individuals may have different brain lateralization, introducing an important confound to the study. Therefore, only right-handed individuals will be included in the study. This will be determined via demographics questionnaire.
* Individuals who have hearing deficits (\>25dB at 500+ Hz), visual deficits (\>20/40), serious emotional problems, certain neurological conditions (e.g., uncontrolled seizure disorders) will not be included. This will be determined via CABI Screening Forms and Demographics Questionnaire.
* Individuals with certain metals in their bodies or with certain health conditions will not be included. If an individual has braces on their teeth, a cardiac pacemaker; hearing aid; other metal in their body or eyes (which may include certain metallic-embedded tattoos), including but not limited to pins, screws, shrapnel, plates, dentures or other metal objects they will not be included. This will be determined via CABI Screening forms.
* Individuals with MRI Screening and Contraindication Forms which do not pass MRI Tech review will not be included.
* Individuals with TMS Screening Forms which do not pass TMS Tech review will not be included.
18 Years
30 Years
ALL
Yes
Sponsors
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Georgia State University
OTHER
Responsible Party
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Rachael Marie Harrington
Assistant Professor
Locations
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Georgia State University
Atlanta, Georgia, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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H23282
Identifier Type: -
Identifier Source: org_study_id
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