Impact of Theta Burst Stimulation Over the Left DLPFC on Language Switching
NCT ID: NCT03148470
Last Updated: 2020-04-22
Study Results
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View full resultsBasic Information
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COMPLETED
NA
41 participants
INTERVENTIONAL
2016-09-30
2019-07-31
Brief Summary
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Detailed Description
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Clinical observations and neuroimaging studies seem to confirm the role of executive functions and frontal structures in language processing in bilingual subjects.
Repetitive transcranial magnetic stimulation, such as for example theta burst stimulation (TBS), is increasingly being used as a valuable tool for neuroscientists investigating the underlying mechanisms of cognitive functions. Case studies have shown a change in language switching after bilingual patients received repetitive magnetic stimulation to the left DLPFC. However, there is no study investigating the effect of TBS applied to the DLPFC on language switching in healthy participants.
Procedure:
A planned total of 40 unbalanced bilingual participants will be included. Half of the participants will receive inhibitory theta burst stimulation (continuous TBS), the other half excitatory theta burst stimulation (intermittent TBS). After TBS, different language and nonverbal tasks will be performed while an EEG is measured. Before being stimulated, each subject will conduct the same tasks with a sham-TBS as a baseline measure.
Conditions
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Study Design
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RANDOMIZED
FACTORIAL
BASIC_SCIENCE
DOUBLE
Study Groups
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intermittent theta burst stimulation
intermittent theta burst stimulation (iTBS) + Sham iTBS
Sham iTBS
Placebo stimulation for the iTBS group
intermittent theta burst stimulation (iTBS)
Excitatory theta burst stimulation
continuous theta burst stimulation
continuous theta burst stimulation (cTBS) + Sham cTBS
Sham cTBS
Placebo stimulation for the cTBS group
continuous theta burst stimulation (cTBS)
inhibitory theta burst stimulation
Interventions
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Sham iTBS
Placebo stimulation for the iTBS group
Sham cTBS
Placebo stimulation for the cTBS group
intermittent theta burst stimulation (iTBS)
Excitatory theta burst stimulation
continuous theta burst stimulation (cTBS)
inhibitory theta burst stimulation
Eligibility Criteria
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Inclusion Criteria
* 18-45 years of age
* right-handedness
Exclusion Criteria
* brain surgery, traumatic brain injuries
* cardiac pacemaker, metallic objects in the head
* history of neurological diseases or severe psychiatric disorders
* drug use (alcohol, psychoactive medication)
* strong headache
* pregnancy
18 Years
45 Years
ALL
Yes
Sponsors
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Jean-Marie Annoni
OTHER
Responsible Party
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Jean-Marie Annoni
Prof. Dr. med.
Principal Investigators
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Jean-Marie Annoni, Prof. Dr.
Role: PRINCIPAL_INVESTIGATOR
University of Fribourg
Locations
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Laboratory for Cognitive and Neurological Sciences
Fribourg, , Switzerland
Countries
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References
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Holtzheimer P, Fawaz W, Wilson C, Avery D. Repetitive transcranial magnetic stimulation may induce language switching in bilingual patients. Brain Lang. 2005 Sep;94(3):274-7. doi: 10.1016/j.bandl.2005.01.003.
Lefaucheur JP, Andre-Obadia N, Antal A, Ayache SS, Baeken C, Benninger DH, Cantello RM, Cincotta M, de Carvalho M, De Ridder D, Devanne H, Di Lazzaro V, Filipovic SR, Hummel FC, Jaaskelainen SK, Kimiskidis VK, Koch G, Langguth B, Nyffeler T, Oliviero A, Padberg F, Poulet E, Rossi S, Rossini PM, Rothwell JC, Schonfeldt-Lecuona C, Siebner HR, Slotema CW, Stagg CJ, Valls-Sole J, Ziemann U, Paulus W, Garcia-Larrea L. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin Neurophysiol. 2014 Nov;125(11):2150-2206. doi: 10.1016/j.clinph.2014.05.021. Epub 2014 Jun 5.
Nardone R, De Blasi P, Bergmann J, Caleri F, Tezzon F, Ladurner G, Golaszewski S, Trinka E. Theta burst stimulation of dorsolateral prefrontal cortex modulates pathological language switching: A case report. Neurosci Lett. 2011 Jan 10;487(3):378-82. doi: 10.1016/j.neulet.2010.10.060. Epub 2010 Oct 29.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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SNF325130_156937_4
Identifier Type: -
Identifier Source: org_study_id
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