Motor Control During Rapid Eye Movement (REM) Sleep Behaviour Disorder
NCT ID: NCT01886131
Last Updated: 2017-02-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
3 participants
INTERVENTIONAL
2013-06-30
2014-07-31
Brief Summary
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Detailed Description
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In the off phases, the plasmatic levels of dopaminergic drugs are the lowest. The plasmatic levels of dopaminergic drugs are also very low during nocturnal sleep.
Nevertheless, PD patients may show vigorous and rapid movements during REM Behaviour Disorder (RBD). Thirty-three to 46% of the patients with PD have RBD.
Akinesia and bradykinesia are the consequence of a hyperactivity of the SubThalamic Nuclei (STN). The electrophysiological correlate of this hyperactivity causing akinesia and bradykinesia is represented by STN beta activity, recorded by local field potentials.
STN beta activity is not present during the execution of a voluntary movement at an "on" phase. Levodopa therapy, which can revert akinesia and bradykinesia, also suppress STN beta activity in PD patients The STN is the surgical target for Deep Brain Stimulation (DBS) of the basal ganglia to improve the motor symptoms of PD.
The STN has bilateral connections with the laterodorsal nucleus/pedunculopontine tegmentum (LDT/PPN), a key structure for REM sleep regulation.
The investigators hypothesize that during the execution of the phasic motor behaviours of RBD the pattern of discharge of STN differs from the one observed during voluntary movements in the "off" phase, in PD patients. In other terms, we expect the STN beta activity to disappear during the execution of phasic motor behaviors of RBD.
Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Synchronised video-polysomnography
Synchronised video-polysomnography
We will record the electrical activity of the STN (local field potentials) during the 2 consecutive nights following the implantation of the electrodes in the STN for DBS. In this period, the deep brain stimulator will not yet be connected to the intracranial electrodes.
The intracranial EEG signal from the STN will be synchronised with the scalp EEG and other video-polysomnographic parameters.
The STN recordings during the phasic movements of RBD will be compared to the recordings obtained at the same level during a motor task.
Interventions
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Synchronised video-polysomnography
We will record the electrical activity of the STN (local field potentials) during the 2 consecutive nights following the implantation of the electrodes in the STN for DBS. In this period, the deep brain stimulator will not yet be connected to the intracranial electrodes.
The intracranial EEG signal from the STN will be synchronised with the scalp EEG and other video-polysomnographic parameters.
The STN recordings during the phasic movements of RBD will be compared to the recordings obtained at the same level during a motor task.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* having RBD according to the International Classification of Sleep Disorders, 2nd edition (ICSD-2) criteria
* Eligible to neurosurgical treatment of PD by implantation of intracranial electrodes for the DBS of STN
* Giving a written informed consent
* Affiliated to the French social security program
Exclusion Criteria
* Cognitive impairment which may compromise the understanding and patient's participation to the protocol (Mattis dementia rating scale score ≥ 136)
* Patient under guardianship, trusteeship or judicial protection
* Pregnancy or breastfeeding
* Patient participating to another clinical research study in the same period
35 Years
70 Years
ALL
No
Sponsors
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Grenoble Institut des Neurosciences
OTHER
University Hospital, Toulouse
OTHER
Responsible Party
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Principal Investigators
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Pietro-Luca RATTI, MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Toulouse
Locations
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University Hospital of Purpan
Toulouse, Midi-Pyrénées, France
University Hospital of Rangueil
Toulouse, Midi-Pyrénées, France
Countries
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References
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AASM (2005). International classification of sleep disorders, 2nd ed.: Diagnostic and coding manual. Westchester, IL, American Academy of Sleep Medicine.
Benarroch EE. Subthalamic nucleus and its connections: Anatomic substrate for the network effects of deep brain stimulation. Neurology. 2008 May 20;70(21):1991-5. doi: 10.1212/01.wnl.0000313022.39329.65. No abstract available.
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Other Identifiers
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AOL2012
Identifier Type: OTHER
Identifier Source: secondary_id
12 388 02
Identifier Type: -
Identifier Source: org_study_id
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