Functional Implication of Corpus Callosum in Voluntary Strength in COPD Patients

NCT ID: NCT03807258

Last Updated: 2020-01-13

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 22 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-10-20
• Study Completion Date: 2019-03-30

Brief Summary

Patients with COPD have lower capability of activating their muscles. At the cortical level, force production is not only controlled by contralateral primary motor cortex but also by ipsilateral motor cortex. The aim of this study is to determine whether ipsilateral areas are functionally impaired in COPD.

Detailed Description

Chronic obstructive pulmonary disease (COPD) patients exhibit not only respiratory symptoms but also a peripheral muscular weakness. This weakness is characterized by a loss in strength, harmful for the patients' life quality and vital prognosis (Swallow et al., 2007). Even if many studies have enlightened damages at a peripheral level, the muscular atrophy itself cannot totally explain the loss in force (Menon et al., 2012). Furthermore, the contractile properties of COPD muscles fibres are preserved (Debigare et al., 2003). Consequently, peripheral muscle weakness cannot only be explained by peripheral factors and central structures must be investigated.

At the central level, it is admitted that force production is controlled by the activation of contralateral motor areas. In COPD, these areas were found to be less activated than in controls during force production (Alexandre et al., 2014). However, recent studies bring the evidence that ipsilateral motor areas are also mobilized to cope demand during such task. The activation of ipsilateral areas is possible through inter hemispheric pathways, as the corpus callosum. Recently, the integrity of the corpus callosum have been linked to the capability of activating the ipsilateral motor cortex (Chiou et al., 2014) during force production. This is of concern knowing that several studies reported white matter lesions in the brain of COPD patients (Dodd et al, 2012) and more precisely in regions containing the corpus callosum (Lahousse et al., 2013).

Therefore, we hypothesize that COPD patients have a lower capability of activating their ipsilateral motor cortex during force production compared to controls.

Conditions

Neurophysiology; Physiology

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

COPD patients group

COPD patients undergoing transcranial magnetic stimulation (TMS) evaluations.

Group Type: EXPERIMENTAL

Transcranial magnetic stimulation (TMS)

Intervention Type: OTHER

Evaluations by TMS

Controls group

Healthy matched controls undergoing transcranial magnetic stimulation (TMS) evaluations.

Group Type: ACTIVE_COMPARATOR

Transcranial magnetic stimulation (TMS)

Intervention Type: OTHER

Evaluations by TMS

Interventions

Transcranial magnetic stimulation (TMS)

Evaluations by TMS

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Health insurance
• Patients : COPD Gold II-IV

Exclusion Criteria

• Pregnant women
• Seizures
• Unable to give written consent
• Metalic object above shoulders
• Dermatological issue concerning surface electrodes
• Caffeine consumption > 4 coffee / day
• Neurological disorders
• Opioid-based treatment
• Patients : recent exacerbation (< 4 weeks)
• Patients : rehabilitation in previous 1 year

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

5 Santé

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Nicolas Oliver, MD

Role: PRINCIPAL_INVESTIGATOR

5 Santé

Locations

Cliniques du Souffle

Lodève, Herault, France

Cliniques du Souffle

Osséja, Pyrenees Orientales, France

Countries

France

Other Identifiers

5S_PHYCOM

Identifier Type: -

Identifier Source: org_study_id