Role of the Posterior Parietal Cortex in the Processing of Sensory Information

NCT ID: NCT03386188

Last Updated: 2020-08-25

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-01-31
• Study Completion Date: 2021-07-18

Brief Summary

Although the primary motor cortex is considered has the common final pathway of motor commands, it is influenced by several structures as, for example, the premotor cortex and the posterior parietal cortex which are involved in motor planning and programming and which integrates movement-induced sensory impute (parieto-frontal circuits). Several studies have shown that there are some direct functional connections between the premotor cortex and the posterior parietal cortex and from these two regions to the primary motor cortex. The posterior parietal cortex can then be considered as a sensorimotor interface whose function in planification and motor control of upper limb is well demonstrated. The hypothesis is that the posterior parietal cortex could participate to the modulation of motor cortex excitability by proprioceptive sensory inputs namely long latency afferent inhibition and afferent induced facilitation.

Conditions

Healthy Subject

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Healthy arm

posterior parietal cortex (PPC) transitory inactivation

Group Type: EXPERIMENTAL

Transcranial Magnetic Stimulation (TMS)

Intervention Type: DEVICE

Transitory inactivation of the posterior parietal cortex and measure of sensorimotor integration.

Electrical Muscle Activity (EMG)

Intervention Type: DEVICE

Electrodes for the collection of EMG activity will be glued on the skin next to the first interosseus dorsalis muscle, the Abductor digiti minimi, the Extensor carpi radialis and the Abductor pollicis brevis. EMG signals will be stored on computer for off-line analysis using Signal © software (Cambridge Electronic Design, Cambridge, UK)

Interventions

Transcranial Magnetic Stimulation (TMS)

Transitory inactivation of the posterior parietal cortex and measure of sensorimotor integration.

Intervention Type: DEVICE

Electrical Muscle Activity (EMG)

Electrodes for the collection of EMG activity will be glued on the skin next to the first interosseus dorsalis muscle, the Abductor digiti minimi, the Extensor carpi radialis and the Abductor pollicis brevis. EMG signals will be stored on computer for off-line analysis using Signal © software (Cambridge Electronic Design, Cambridge, UK)

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Right handed
• No neurological troubles
• Informed consent signed
• Affiliated to a social security

Exclusion Criteria

• Psychiatric antecedent
• Neurological disease
• Contra-indication to TMS
• Under psychiatric treatment
• Pregnancy
• Contra-indication to MRI

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Lille

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Philippe Derambure, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Lille

Locations

Hôpital Roger Salengro, CHRU de Lille

Lille, , France

Site Status: RECRUITING

Countries

France

Central Contacts

Philippe Derambure, MD,PhD

Role: CONTACT

philippe.derambure@chru-lille.fr

Other Identifiers

2014-A01507-40

Identifier Type: OTHER

Identifier Source: secondary_id

2014_32

Identifier Type: -

Identifier Source: org_study_id