Verticality Perception - Multisensory Contribution

NCT ID: NCT02212704

Last Updated: 2024-11-01

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 12 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-10-31
• Study Completion Date: 2015-11-30

Brief Summary

The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects. To implement this assessment experimentally, the investigators will use a motor-driven 3D-turntable and a thermoplastic mask to keep the head in a stable, either roll-tilted (±30°) or aligned with the trunk. The investigators will then obtain measurements of the subjective visual vertical in seven different whole-body roll positions (max. 90° roll-tilt). Analysis will be driven by a state-of-the art Bayesian integration model. The investigators hypothesize that different sensory input signals are combined in a statistically optimal fashion.

Conditions

Verticality Perception in Healthy Human Subjects; Individual Contribution of Different Sensory Systems

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Vestibular stimulation

This is the experimental paradigm applied in all participants

Group Type: EXPERIMENTAL

Vestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk)

Intervention Type: OTHER

3D-video-head impulse testing

Intervention Type: OTHER

Evaluation of semicircular canal function. This intervention is part of the screening to determine suitability for this study

Vestibular-evoked myogenic potentials (VEMPs)

Intervention Type: OTHER

Evaluation of otolith function. This intervention is part of the screening to determine suitability for this study

Interventions

Vestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk)

Intervention Type: OTHER

3D-video-head impulse testing

Evaluation of semicircular canal function. This intervention is part of the screening to determine suitability for this study

Intervention Type: OTHER

Vestibular-evoked myogenic potentials (VEMPs)

Evaluation of otolith function. This intervention is part of the screening to determine suitability for this study

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• ages 18-60 years
• informed consent

Exclusion Criteria

• peripheral-vestibular deficit
• disturbed consciousness
• history of sensory deficits
• visual field deficits
• other neurological or systemic disorder which can cause dementia or cognitive dysfunction
• intake of antidepressants, sedatives, or neuroleptics
• pregnancy, unless excluded by a negative pregnancy test
• known neck pain or status post neck trauma

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Zurich

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Dominik Straumann, Prof, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital Zurich, Dept. of Neurology

Locations

University Hospital Zurich, Dept. of Neurology

Zurich, Canton of Zurich, Switzerland

Countries

Switzerland

Other Identifiers

perception_head_roll_zurich

Identifier Type: -

Identifier Source: org_study_id