Task-dependent Operation of a Mechanism Intracortical Inhibition in Dystonia

NCT ID: NCT03381456

Last Updated: 2017-12-22

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-04-30
• Study Completion Date: 2017-04-30

Brief Summary

Cortical excitability depends on inhibitory mechanisms efficiency among which long latency intracortical inhibition (LICI) can be studied by paired pulses transcranial magnetic stimulation (TMS). Some recent evidences suggest that LICI may be one of the mechanisms by which the motor comment is adapted to the ongoing motor task with LICI strength being dependent on task complexity. In writer cramp and musician cramp, two forms of dystonia, the cortical excitability is not correctly modulated in some complex gestures. the hypothesis is that this task dependent perturbation of excitability in writer cramp could be due to a lack of LICI efficiency.

Conditions

Dystonia, Primary

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Healthy subject

LICI

Group Type: EXPERIMENTAL

LICI

Intervention Type: OTHER

Paired pulse TMS to measure LICI and late cortical disinhibition

Dystonic subject

LICI

Group Type: EXPERIMENTAL

LICI

Intervention Type: OTHER

Paired pulse TMS to measure LICI and late cortical disinhibition

Interventions

LICI

Paired pulse TMS to measure LICI and late cortical disinhibition

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patient with hand dystonia : writers cramp
• Subject affiliated to social security regimen.

For healthy volunteers :

• Healthy volunteer without neurological disorders based on sensorimotor examination.
• Subject affiliated to social security regimen.

Exclusion Criteria

• Subject unable to receive informed consent (dementia).
• Contraindication to Transcranial Magnetic Stimulation(TMS) (epilepsia, intracranial metalic foreign object, hearing device, cochlear implant).
• Patient using a psychotrope treatment.
• Patient under guardianship or curatorship.
• Pregnant or nursing women.
• Patient with a cardiac stimulator.

For healthy volunteers only :

• Abnormal neurological evaluation based on sensorimotor examination or neurological history ( epilepsy, stroke ; brain or spinal cord surgery ; history of neurological disease affective sensitive and motor control)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Lille

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Philippe Derambure, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Lille

Locations

Hôpital Roger Salengro, CHRU de Lille

Lille, , France

Countries

France

Other Identifiers

2014-A00244-43

Identifier Type: OTHER

Identifier Source: secondary_id

2013_51

Identifier Type: -

Identifier Source: org_study_id