Agency in Dystonia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

76 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-23

Study Completion Date

2022-12-20

Brief Summary

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In this study, using computerized cognitive assessments combined with multi-modal neuroimaging approach investigators aim to address three specific questions on patients with cervical and myoclonus dystonia:

(i) investigate various aspects of the sense of agency and relationship to the severity of dystonia symptoms, (ii) characterize the possible link between abnormalities of movement perception and alteration of sense of agency in dystonia, (iii) (identify the neuronal underpinnings of the defective sense of agency in dystonia.

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Detailed Description

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This is a single-centre, two-group ( dystonia and control), case-control study using behavioural and novel multimodal neuroimaging techniques to address the study aims.

The battery of the tasks will include explicit-agency tasks, a visual discrimination task on objects movement perception. The magnetic resonance acquisition protocol will include MP2RAGE structural (10 min duration), multi echo (3 echo times) multiband (MB factor 4) resting state functional neuroimaging (15 minutes duration) and multi shell diffusion imaging sequence (15 minutes duration)

Conditions

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Dystonia, Primary

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Two groups study : patients versus healthy controls

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Patients

25 patients with cervical and 25 patients with myoclonus dystonia

Group Type OTHER

Behavioral testing - computerized tasks

Intervention Type BEHAVIORAL

Cognitive behavioral testing and cerebral MRI

Controls

50 healthy volunteers matched to patents ( age, sex)

Group Type OTHER

Behavioral testing - computerized tasks

Intervention Type BEHAVIORAL

Cognitive behavioral testing and cerebral MRI

Interventions

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Behavioral testing - computerized tasks

Cognitive behavioral testing and cerebral MRI

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* diagnosis of isolated adult-onset cervical dystonia (CD) or myoclonus dystonia (MD);
* duration of disease of more than one year
* no botulinum toxin injection for at least three months before the study
* normal or corrected-to-normal vision.

Exclusion Criteria

* any neurological history except for dystonia,
* history of dopamine antagonist treatment,
* secondary dystonia,
* dystonia in the upper limbs,
* inability to maintain gaze straight.

Minimum Eligible Age

15 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes