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Contribution of the Cerebellum In Sensory-motor Adaptation Via Gamma Oscillations: the Case of Dystonia

NCT ID: NCT02073630

Last Updated: 2017-11-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

63 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-02-28

Study Completion Date

2016-08-31

Brief Summary

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Dystonia, a disabling disease with uncontrolled movement disorders was considered to be a manifestation of basal ganglia dysfunction, yet there is accumulating evidence from animal and human experiments that the cerebellum plays a prominent role in the pathophysiology of dystonia. Our recent results suggest a deficient cerebellar sensory encoding in dystonia, resulting in a decoupling of the motor component from the afferent information flow resulting from changes in the environment. An overall loss of gabaergic-mediated inhibition is at the forefront in dynamic changes in neural circuitry described in dystonia. In the mature brain gabaergic control the generation of temporal synchronies and oscillations in the glutamatergic neurons. Taken these all together with the results of a pilot experiment, the investigators hypothesize that deficient synchronies in the fast gamma range are one of the key mechanisms leading to abnormal communication inside the cerebello-cortical network in dystonia. The investigators aim first to demonstrate it by means of MEG (Magneto encepholography) recordings allowing to reconstruct the spatio-temporal dynamics of gamma oscillations in the nodes of the cerebello-cortical network. The investigators then aim to re-establish (if lost) or boost (if decreased) the defective synchronies by applying to the cerebellum at high gamma frequency a non invasive transcranial alternative current stimulation.

Detailed Description

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Conditions

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Primary Dystonia

Keywords

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magnetoencephalography non invasive brain stimulation cerebellum gamma rhythms

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Healthy subjects

healthy subjects will receive either sham or active cerebellar stimulation

Group Type OTHER

active cerebellar stimulation

Intervention Type OTHER

sham cerebellar stimulation

Intervention Type OTHER

Dystonia

dystonic patients will receive either sham or active cerebellar stimulation

Group Type OTHER

active cerebellar stimulation

Intervention Type OTHER

sham cerebellar stimulation

Intervention Type OTHER

Interventions

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active cerebellar stimulation

Intervention Type OTHER

sham cerebellar stimulation

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* primary upper limb dystonia
* normal physical and neurological examination except for dystonia
* no treatment with botulinum toxin during the three months preceding the study

Exclusion Criteria

* Writing tremor
* current neurological or psychiatric illness other than dystonia
* uncontrollable medical problems not related to dystonia
* pregnancy, breast feeding women and women who are of childbearing age and not practicing adequate birth control
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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sabine meunier, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Institut National de la Santé Et de la Recherche Médicale, France

Locations

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ICM GH Pitié Salpetrière

Paris, , France

Site Status

Countries

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France

Other Identifiers

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C13-45

Identifier Type: -

Identifier Source: org_study_id