Can Short Latency Afferent Inhibition Give us Clues to Better DYT 1 Dystonia Treatments?
NCT ID: NCT01435681
Last Updated: 2016-09-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
5 participants
OBSERVATIONAL
2012-05-31
2016-08-31
Brief Summary
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The sensory system is the body's sense organs - smell, sight, sound, etc. - and the motor cortex is the part of your brain where nerve impulses control voluntary muscle activity.
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Detailed Description
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If you are a DYT1 dystonia patient, then this study involves up to three visits. The first visit (before DBS surgery) will last about 4 hours and the second and third visits (after DBS surgery) will last about 4 hours as well. These visits will include a complete physical and neurological exam, video recorded dystonia and mood rating scales, followed by electromyography (EMG) and TMS sessions. Subjects who have already undergone DBS surgery may participate in applicable visits based on the length of time since their DBS surgery.
If you are a control subject, this study involves one visit, about 4 hours long. This visit will include TMS and EMG sessions.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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DYT-1 Postive
This group includes those participants who enroll having a genetically confirmed primary generalized dystonia diagnosis.
No interventions assigned to this group
Control
This group includes healthy subjects between the ages of 18 and 80.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Diagnosis and genetic test results confirming diagnosis of DYT1 dystonia.
* Currently treated with medications and enrolled in evaluation process for DBS surgery to confirm candidacy - OR -
* Previous DBS surgery
Exclusion Criteria
* Family or personal history of medication refractory epilepsy.
* Pregnancy: due to the frequent visits over a prolonged period and the lack of Information on the safety of TMS during pregnancy, pregnant women will not be eligible to participate in this study. Women of childbearing potential will be eligible to participate, provided that they are using adequate contraception during TMS treatments.
This study is accepting healthy volunteers, aged 18-80, as control subjects. Control subjects will not undergo DBS surgery.
* Cannot have family history or personal history of medication refractory epilepsy
10 Years
80 Years
ALL
Yes
Sponsors
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Brain and Spinal Cord Injury Research Trust Fund
OTHER
University of Florida
OTHER
Responsible Party
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Principal Investigators
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Aparna Wagle Shukla, M.D.
Role: PRINCIPAL_INVESTIGATOR
University of Florida
Locations
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UF Center for Movement Disorders and Neurorestoration
Gainesville, Florida, United States
Countries
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Related Links
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UF Center for Movement Disorders \& Neurorestoration
Other Identifiers
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405-2011
Identifier Type: -
Identifier Source: org_study_id
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