Altered Structural-functional Connectivity Coupling on Chronic Subcortical Stroke

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2025-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The current study aims to reveal the SC-FC coupling pattern and its relationship with motor function in post-stroke survivors with motor dysfunction by multimodal MRI.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Assessment of Brain Activity During Complex Fine Hand Movements: an fMRI Study

NCT03965338

Regional Anaesthesia Functional Magnetic Resonance Imaging

COMPLETED

Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

NCT06598150

Stroke Hemiparesis

RECRUITING NA

Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex

NCT04431011

Normal Physiology

COMPLETED

Study of Structural and Functional Brain Connectivity Changes in ALS (CoALS-II)

NCT05404867

Amyotrophic Lateral Sclerosis

COMPLETED NA

The Brain Activation During Different Motor Patterns in Healthy Adults

NCT04868929

Neurosciences

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Stroke is the leading cause of death and disability in China. Recently, many previous studies suggested exploring the functional reorganization of the motor function among post-stroke survivors is urgent to be solved in both clinical work and applied basic research. Investigating the structural connectivity (SC) of the brain could visualize the anatomical connections between different brain regions and exploring the functional connectivity (FC) could reveal the functional activity patterns of the human brain in resting- and task- states. Previous studies suggested that SC-FC coupling analysis may shed light on exploring biological markers for the assessment and treatment of motor deficits in post-stroke survivors. The current study aims to reveal the SC-FC coupling pattern and its relationship with motor function in post-stroke survivors with motor dysfunction by multimodal MRI.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Stroke Motor Activity

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Stroke group

Chronic subcortical stroke participants with motor dysfunction

No interventions assigned to this group

Healthy controls group

Well-matched healthy controls

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Comply with the diagnostic criteria of "Stroke" in the 2010 "Guidelines for the Prevention and Treatment of Cerebrovascular Diseases in China," and confirmed by head CT or MRI.
2. First onset unilateral subcortical stroke (basal ganglia, thalamus, internal capsule, corona radiata, lateral ventricles, etc.).
3. Age ranged from 30 to 75 years old.
4. Right-handedness before stroke.
5. Greater than three months since stroke onset and Brunnstrom graded as III-VI; 6. The condition and vital signs are stable.

7\. Sign the informed consent form.

Exclusion Criteria

1. Any contraindications for the MRI examination.
2. History of other brain diseases and drug dependency.
3. Unstable conditions or accompanied by malignant and rapidly progressing diseases, such as severe atrial fibrillation.
4. Serious communication barriers, cognitive impairment, or cooperation with difficulties.

Minimum Eligible Age

30 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No