rTMS Improves Functions in Spinocerebellar Ataxia

NCT ID: NCT05973019

Last Updated: 2023-10-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-09-01

Study Completion Date

2024-08-01

Brief Summary

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Spinocerebellar ataxia (SCA) is a group of inherited brain disorders. SCA often result in poor limb coordination. This study aims to discover the effects of repeated transcranial magnetic stimulation (rTMS) on balance \& gait in SCA. The hypothesis of this study is that rTMS might improve SCA limb functional performance.

Detailed Description

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rTMS has been shown that improves walking speed and balance performance, however, the optimal treatment protocols have not been approved. Past studies used different frequencies 1 Hz, 5 Hz and 10 Hz to improve functional performance. The results might be affected by the types of SCA. In this study, we will focus on the SCA type 3 to assess the effects on high frequency (10 Hz) of rTMS intervention.

Conditions

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Transcranial Magnetic Stimulation Spinocerebellar Ataxias

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

All subjects receive 12 times rTMS intervention
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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rTMS with 10 Hz

6 times/per week for 2 weeks, total 12 times rTMS.

Group Type EXPERIMENTAL

Repetitive Transcranial Magnetic Stimulation (rTMS)

Intervention Type DEVICE

6 times/per week for 2 weeks, total 12 times rTMS with 10 Hz.

Interventions

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Repetitive Transcranial Magnetic Stimulation (rTMS)

6 times/per week for 2 weeks, total 12 times rTMS with 10 Hz.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* SCA type 3
* independently walk with/without an assistive device
* SARA greater than 3

Exclusion Criteria

* Epilepsy history
* Unstable blood pressure
* Brain Trauma
* Alcoholism, drug abuse, antipsychotics drug use
* Metallic hardware (e.g. - cochlear implants, brain stimulators or electrodes, aneurysm clips) anywhere in head.
* Dementia, depression
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Changhua Christian Hospital

OTHER

Sponsor Role lead

Responsible Party

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Sen-yung Liu

Chief Medical Officer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sen Yung Liu, MD

Role: PRINCIPAL_INVESTIGATOR

Changhua Christian Hospital

Locations

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Changhua christian hospital

Changhua, , Taiwan

Site Status RECRUITING

Changhua christian hospital

Changhua, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Sen Yung Liu, MD

Role: CONTACT

88647238595 ext. 7427

Facility Contacts

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Sen Yung Liu, MD

Role: primary

88647238595 ext. 7022

Other Identifiers

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230425

Identifier Type: -

Identifier Source: org_study_id

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