Reshaping the Motor Engram - An Online Crowdsourcing Study.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

404 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-08-01

Study Completion Date

2023-06-30

Brief Summary

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A critical point in learning and memory research is whether memories, once consolidated, remain unchanged or whether they continue to undergo plastic changes and remodeling. While previous research has focused on experimental destabilization during early stages of the memory life cycle, i.e., during encoding or early consolidation, experimental data that provides information about the effect of destabilization interventions on well-consolidated memories is still missing. This is particularly true for the procedural memory domain, such as learning a sensorimotor skill. This project is designed to characterize the effect of a single behavioral interference intervention on a previously consolidated sensorimotor skill in a large sample of healthy volunteers recruited through an online crowdsourcing platform. In a longitudinal design, participants will perform an implicit sequence learning task over five consecutive sessions, followed by an interference intervention in session six and a follow-up evaluation of the stability of the learned skill in session seven. The experimental design includes two levels of sequential information (spatial and temporal), which allows the testing of the specificity of the interference intervention. Behavioral performance throughout the experimental sessions is acquired via the manual input on the participants' computer keyboards and used to extract the learning rate and the interference effect (primary outcome).

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Detailed Description

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Conditions

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Healthy Volunteers

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Interference on sequence 1

The interference intervention (session six) will be applied to one of the two previously learned sequences (temporal).

Group Type EXPERIMENTAL

Interference through learning of a competing motor skill.

Intervention Type BEHAVIORAL

Interference through the learning of a competing motor skill.

Interference on sequence 2

The interference intervention (session six) will be applied to one of the two previously learned sequences (spatial).

Group Type EXPERIMENTAL

Interference through learning of a competing motor skill.

Intervention Type BEHAVIORAL

Interference through the learning of a competing motor skill.

Interference on sequences 1 and 2

The interference intervention (session six) will be applied to both of the two previously learned sequences (temporal and spatial).

Group Type EXPERIMENTAL

Interference through learning of a competing motor skill.

Intervention Type BEHAVIORAL

Interference through the learning of a competing motor skill.

No interference

The interference intervention (session six) will be applied.

Group Type SHAM_COMPARATOR

No interference

Intervention Type BEHAVIORAL

No interference through the continuation of learning same motor skill

Interventions

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Interference through learning of a competing motor skill.

Interference through the learning of a competing motor skill.

Intervention Type BEHAVIORAL

No interference

No interference through the continuation of learning same motor skill

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* registered Amazon Mechanical Turk users (called 'workers')
* with \>95% approval rate on all previous Amazon Mechanical Turk assignments
* location in North America or Europe
* ≥18 years of age
* not having participated in this experiment before