Sugar-sweetened Beverages Influence Benefits of Exercise in Overweight Adults

NCT ID: NCT03576703

Last Updated: 2018-07-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 26 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-10-24
• Study Completion Date: 2015-07-09

Brief Summary

The objective of this study was to determine how metabolic and inflammatory effects of physical exercise in overweight individuals are altered when sugar-sweetened beverages (SSB) are consumed after physical exercise. A randomized, controlled crossover trial was performed in which participants performed exercise with and without the ingestions of SSB during exercise or a non-exercise control condition to evaluate metabolic and inflammatory responses one day after the exercise and or SSB treatment.

Detailed Description

Participants: Women (n=24; 18-55 y) with a BMI > 25 and < 35 kg·m-2 who are sedentary to moderately active were recruited to participate. Research Design: This study was a randomized, counter-balanced, cross-over clinical trial consisting of three experimental conditions in which each participant served as her/his own control. Assessments of health history, physical activity (to confirm that participants were physically inactive), anthropometrics, resting metabolic rate, and aerobic capacity were made during an initial laboratory visit. Participants performed three different study conditions, typically separated by one week, thus women were not tested in a specific menstrual cycle phase. Participants recorded their diet the day before and the morning of the first condition and replicated this for the second and third conditions. On the study days, participants consumed their breakfast prior to 9:00 AM and arrived in the lab at 11 AM. The three conditions were performed in randomized order. In the control condition (CON), participants rested quietly for 1 hour. In the remaining two conditions, participants performed 45 minutes of treadmill exercise at 11 AM. Following the rest or exercise period, subjects were provided energy balanced diets. Total energy intake was balanced across exercise conditions and appropriately adjusted for the lack of exercise in the CON condition. At 7 AM on the following morning, following an overnight fast, an oral glucose tolerance test (OGTT) was performed. Measurements were made to determine fasting glucose, insulin and lipid panel, 2-hour OGTT glucose, insulin sensitivity (SI OGTT), early (0-30 min) and late (30-120 min) glucose stimulated insulin secretion (GSIS) based on c-peptide concentrations. Indirect calorimetry was also performed to determine resting carbohydrate and fat oxidation and metabolic flexibility, defined as the change in respiratory exchange ration (RER) during the OGTT. Interleukin-6, tumor necrosis factor-alpha, and reactive oxygen species were measure before, 60, and 120 minutes during the OGTT to assess the inflammation response.

Conditions

Inflammation; Insulin Sensitivity

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

EX+H2O

Exercise and diet that did not include SSB

Group Type: EXPERIMENTAL

Exercise with and without SSB ingestion

Intervention Type: OTHER

Consumption of a prescribed diet with and without SSB and performance of moderate aerobic exercise or resting/control

EX+SSB

Exercise and diet that includes SSB

Group Type: EXPERIMENTAL

Exercise with and without SSB ingestion

Intervention Type: OTHER

Consumption of a prescribed diet with and without SSB and performance of moderate aerobic exercise or resting/control

CONTROL

No exercise and diet that did not include SSB

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Exercise with and without SSB ingestion

Consumption of a prescribed diet with and without SSB and performance of moderate aerobic exercise or resting/control

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• BMI > 25 and < 35 kg/m2
• sedentary to moderately active

Exclusion Criteria

• inflammatory conditions
• heart disease, diabetes, and other diseases that may interfere with the safety of exercise or other experimental procedures
• allergy to wheat, gluten, dairy, or peanuts
• taking blood pressure, cholesterol lowering, or anti-inflammatory medications
• taking hormone-based birth control with exception of intrauterine device,
• pregnant
• health concerns that make it difficult to participate in study procedures

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Montana State University

OTHER

Sponsor Role: lead

Responsible Party

Mary Miles

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Mary P Miles, PhD

Role: PRINCIPAL_INVESTIGATOR

Montana State University

Other Identifiers

MW CTR-IN 15-746Q-MSU-PG21-00

Identifier Type: -

Identifier Source: org_study_id