Hyperglycemia, Exercise, and Endothelial Function

NCT ID: NCT03651713

Last Updated: 2020-03-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-15

Study Completion Date

2019-10-21

Brief Summary

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The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days. Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU) structured exercise group.

Detailed Description

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Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are associated with impaired endothelial function. Both a single bout of exercise and chronic exercise training are associated with improvements in vascular endothelial function. It remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.

Conditions

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Endothelial Function Hyperglycemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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GLU+EX

Subjects will consume a 75g glucose beverage three times daily for seven days while participating in five structured aerobic exercise sessions throughout the experimental protocol.

Group Type EXPERIMENTAL

GLU+EX

Intervention Type BEHAVIORAL

Subjects will complete 45 minutes of recumbent cycling at 60-65% of age-predicted maximal heart rate five times over seven days while ingesting a 75g glucose beverage three times daily.

GLU

Subjects will consume a 75g glucose beverage three times daily for seven days without participating in structured aerobic exercise.

Group Type ACTIVE_COMPARATOR

GLU

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume a 75g glucose beverage three times daily over a seven-day period.

Interventions

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GLU+EX

Subjects will complete 45 minutes of recumbent cycling at 60-65% of age-predicted maximal heart rate five times over seven days while ingesting a 75g glucose beverage three times daily.

Intervention Type BEHAVIORAL

GLU

Subjects will consume a 75g glucose beverage three times daily over a seven-day period.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

\- Healthy young men 18-35 years of age.

Exclusion Criteria

* Hypertension,
* Hyperlipidemia,
* Smoking,
* Heart disease,
* Chest pain upon exertion,
* Previous heart surgeries or history of arrhythmias,
* Diabetes,
* Obesity (body mass index ≥30kg/m2),
* Kidney disease,
* Pulmonary disease,
* Autonomic disorders,
* Individuals whom engage in structured exercise (≥30min, ≥2d/wk),
* Current use of medications which influence outcome measures
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Iowa

OTHER

Sponsor Role lead

Responsible Party

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Darren P Casey

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Medical Education Building

Iowa City, Iowa, United States

Site Status

Countries

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United States

Other Identifiers

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201807752

Identifier Type: -

Identifier Source: org_study_id

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