The Effect of an Acute Bout of Exercise on High-sugar Meal Induced Endothelial Dysfunction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-11-30

Study Completion Date

2017-12-31

Brief Summary

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The purpose of this study is to determine if postprandial (after a meal) endothelial (inner lining of blood vessels) dysfunction induced by a high sugar meal improves with a bout of exercise

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Detailed Description

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Endothelial dysfunction is due to an imbalance between vasodilating and vasoconstricting substances produced by the endothelium. An imbalance in these substances limits the ability of the blood vessel to relax in response to a shear stress stimulus. Endothelial dysfunction is a major risk factor for cardiovascular disease.

High-sugar intakes result in postprandial hyperglycemia and endothelial dysfunction. Exercise may attenuate the endothelial dysfunction induced by a high-sugar meal. There are only two studies that have examined the effect of exercise on endothelial dysfunction induced by high-sugar intake. Both studies found that a bout of aerobic exercise attenuated the impaired flow mediated dilation induced by high-sugar ingestion. Neither study measured important markers of endothelial dysfunction such as blood nitric oxide, endothelin I, and angiotensin II concentrations, however. In addition, whether the same results apply to older post-menopausal women is unknown. Understanding how acute exercise affects meal-induced endothelial dysfunction in older women is important given that age is related to endothelial dysfunction and cardiovascular disease.

Conditions

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Endothelial Dysfunction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Exercise Condition

Group Type EXPERIMENTAL

Exercise Condition

Intervention Type OTHER

A bout of exercise in the evening followed by high-sugar meal consumption the following morning

Control Condition

Group Type ACTIVE_COMPARATOR

Control Condition

Intervention Type OTHER

Rest in the evening followed by high-sugar meal consumption the following morning

Interventions

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Exercise Condition

A bout of exercise in the evening followed by high-sugar meal consumption the following morning

Intervention Type OTHER

Control Condition

Rest in the evening followed by high-sugar meal consumption the following morning

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Post-menopausal women
* Must be 45-70 years

Exclusion Criteria

* Use of medications or supplements to lose weight
* Following a weight loss diet
* Smoking
* Heavy alcohol consumption
* Diabetes
* Heart disease
* Stroke
* Liver disease
* Kidney disease
* Untreated thyroid disease
* Anemia
* Uncontrolled hypertension
* Pulmonary disease that prevents exercise
* Orthopedic problems that prevents exercise
* Arthritis problems that prevent exercise
* Musculoskeletal problems that prevent exercise.

Minimum Eligible Age

45 Years

Maximum Eligible Age

70 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes